锌指蛋白6（ZBED6）研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2018-0449

生物技术通报 ›› 2018, Vol. 34 ›› Issue (11): 50-55.doi: 10.13560/j.cnki.biotech.bull.1985.2018-0449

锌指蛋白6（ZBED6）研究进展

解文雅^1,2, 张传海^1,2, 潘登科³, 贺晓云^1,2

1. 中国农业大学食品科学与营养工程学院北京食品营养与人类健康高精尖创新中心,北京 100083;
2. 农业部农业转基因生物安全评价（食用）重点实验室,北京 100083;
3. 中国农业科学院北京畜牧兽医研究所国家畜禽改良研究中心,北京 100193

收稿日期:2018-05-13 出版日期:2018-11-26 发布日期:2018-11-28
作者简介:解文雅,女,硕士研究生,研究方向：营养与食品安全;E-mail：18612928266@163.com

Research Progress on Zinc Finger Protein 6

XIE Wen-ya^1,2, ZHANG Chuan-hai^1,2, PAN Deng-ke³, HE Xiao-yun^1,2

1. Beijing Advanced Innovation Center for Food Nutrition and Human Health,College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083;
2. Key Laboratory of Safety Assessment of Genetically Modified Organism（Food Safety）,Ministry of Agriculture,Beijing 100083;
3. Beijing Institute of Animal Science,Chinese Academy of Agricultural Sciences,Beijing 100193

Received:2018-05-13 Published:2018-11-26 Online:2018-11-28

摘要/Abstract

摘要： 锌指蛋白6（ZBED6）基因是新发现的一个转录调控因子,与肌肉的生长发育密切相关,可调控胰岛素样生长因子2（Insulin-like growth factor 2,IGF2）在内的多种基因的表达,为哺乳动物特有,序列高度保守。IGF2作为重要的生长调节因子,内含子3区域可与ZBED6结合,ZBED6的结合可抑制IGF2表达,进而调控细胞的增殖分化和肌肉的生长发育。总结了目前对ZBED6基因的生理功能研究进展,已有研究表明ZBED6可抑制IGF2的表达,促进骨骼肌、心脏、肝脏、肾脏等器官的生长发育,降低脂肪沉积,体内蛋白质、脂质等生物大分子的代谢过程也随之发生变化,ZBED6在糖尿病、癌症的发展过程中均发挥着重要的调控作用。此外,还总结了影响ZBED6表达的多种因素,包括碱基突变、DNA甲基化、组蛋白修饰以及回文序列等。最后,展望了ZBED6的实际应用潜力,其作为一个与肌肉生长发育密切相关的转录因子,可通过敲除ZBED6促进肌肉生长,为瘦肉型动物的遗传育种提供了新的思路。

关键词: 锌指蛋白6, 胰岛素样生长因子2, 生长发育

Abstract: Zinc finger,BED-type containing 6（ZBED6）is a novel transcription factor that is closely related to the development of skeletal muscle and it regulates the expression of many genes including insulin-like growth factor 2（IGF2）. It is specific for placental mammals and highly conserved among species according to the available genome sequence data. The binding of ZBED6 gene with the intron 3 of key growth regulation factor IGF2 inhibits the expression of IGF2,which then regulate the cell proliferation and the growth of muscle. This article summarized the current research progress on the physiological function of ZBED6. It has been found that ZBED6 may repress the expression of IGF2 and promote the growth of skeletal muscle,heart,liver and kidney;it can reduce fat deposition,resulting in the changing of the metabolism of large molecules such as protein,lipid,etc.,and plays an important regulatory role in the development of diabetes and cancer. In addition,the article summarized the factors affecting the expression of ZBED6,including base mutations,DNA methylation,histone modifications and palindromic sequence. Finally,the article prospects the practical application potential of ZBED6,for instance,ZBED6,as a transcription factor,is closely related to the growth and development of muscle,knocking ZBED6 out may promote muscle growth,which provides new ideas for the genetic breeding of lean animals.

Key words: ZBED6, insulin-like growth factor 2, growth and development

解文雅, 张传海, 潘登科, 贺晓云. 锌指蛋白6（ZBED6）研究进展[J]. 生物技术通报, 2018, 34(11): 50-55.

XIE Wen-ya, ZHANG Chuan-hai, PAN Deng-ke, HE Xiao-yun. Research Progress on Zinc Finger Protein 6[J]. Biotechnology Bulletin, 2018, 34(11): 50-55.

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锌指蛋白6（ZBED6）研究进展

Research Progress on Zinc Finger Protein 6

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