DNA/银纳米簇介导的功能核酸生物传感器研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2019-0963

摘要/Abstract

摘要： DNA/银纳米簇（DNA/Silver nanoclusters,DNA / Ag NCs）是以DNA为模板,NaBH₄和银离子为反应物生成的一种新型荧光纳米材料。近年来,银纳米簇以其出色的光物理性质、良好的生物相容性、低成本、低毒性等优点成为了生物传感器设计及应用研究的一个热点。对DNA/银纳米簇介导的生物传感器的信号输出方式进行分类,并总结了DNA / Ag NCs在体内成像和抑菌方面的应用;最后,对DNA/Ag NCs介导的生物传感器目前存在的不足及今后的发展趋势进行了展望。

关键词: 荧光, 银纳米簇, 生物传感器, 功能核酸

Abstract: DNA/Silver nanocluster（DNA/Ag NCs）is a novel fluorescent nanomaterial produced by using DNA as a template and NaBH₄ and silver ions as reactants. In recent years,silver nanoclusters have become a hotspot in the design and applications of biological sensors due to their excellent photophysical properties,fine biocompatibility,low cost and low toxicity. The signal output methods in DNA/silver nanocluster-mediated biosensor are categorized,and the applications of DNA/Ag NCs in vivo imaging and bacteriostasis are also summarized. Finally,the shortcomings of DNA/Ag NCs-mediated biosensors and their future development trends are prospected.

Key words: fluorescence, silver nanoclusters, biosensors, functional nucleic acids

杨敏, 李舒婷, 杨文平, 李相阳, 许文涛. DNA/银纳米簇介导的功能核酸生物传感器研究进展[J]. 生物技术通报, 2020, 36(6): 245-254.

YANG Min, LI Shu-ting, YANG Wen-ping, LI Xiang-yang, XU Wen-tao. Research Progress on Functional Nucleic Acid Biosensors Mediated by DNA/Silver Nanoclusters[J]. Biotechnology Bulletin, 2020, 36(6): 245-254.

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