果蝇肠道干细胞及肠道菌群的研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2020-0875

摘要/Abstract

摘要：

动物肠道有强大的免疫系统、干细胞及微生态系统,肠道内微生物群在维持正常的肠上皮和免疫功能中发挥重要作用。正常情况下,肠道菌群处于微生态均衡状态,维持共生关系。肠道菌群的变化可通过影响肠上皮细胞引起代谢疾病发生,甚至改变宿主的行为模式。果蝇肠道的生理结构、干细胞增殖与分化机制及其小生境均与哺乳动物存在高度保守性,其肠道菌群结构远没有哺乳动物复杂,因此果蝇是研究宿主-共生菌相互作用的理想模型。将介绍和讨论果蝇肠道共生菌和干细胞增殖与分化的作用机制,对揭示人类肠道相关疾病的发生机制有着重要的科学意义。

关键词: 肠道干细胞, 增殖与分化, 肠道菌群

Abstract:

There are strong immune system,stem cells and micro ecosystem in the intestine of animals. The intestinal microflora plays an important role in maintaining the normal intestinal epithelium and immune function. Under normal conditions,the intestinal microflora of a host is in a state of micro-ecology equilibrium,and its symbiotic relationship is maintained. The change of intestinal microflora can cause metabolic diseases by affecting intestinal epithelial cells,and even change the behavior pattern of the host. The physiological structure,the mechanism of stem cell proliferation and differentiation,and the microhabitat of Drosophila’s gut are highly conserved with mammals. However,the structure of Drosophila intestinal microflora is far less complex than that of mammals. Therefore,Drosophila is an ideal model for studying the interaction between host and symbiotic bacteria. This paper will introduce and discuss the mechanism of the growth and differentiation of the symbiotic bacteria and stem cells in Drosophila’s gut,which is of great scientific significance to reveal the pathogenesis of human gut related diseases.

Key words: intestinal stem cells, proliferation and differentiation, intestinal microbiota

金秋霞, 王思宏, 金丽华. 果蝇肠道干细胞及肠道菌群的研究进展[J]. 生物技术通报, 2021, 37(4): 245-250.

JIN Qiu-xia, WANG Si-hong, JIN Li-hua. Research Progress on Drosophila Intestinal Stem Cells and Intestinal Microflora[J]. Biotechnology Bulletin, 2021, 37(4): 245-250.

图/表 1

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