Abstract: This work aims to investigate the effects of resveratrol on renal tissues of IL-4,IL-5 and IL-13 TH2 inflammatory factors and circulating immunocomplex（CIC）from serum of rats with IgA nephropathy. Ten normal rats were used as the normal group,and the other 40 rats were treated with fetal bovine gamma globulin（BGG）for 9 weeks to become 4 groups of IgA nephropathy（IgAN）rats. Resveratrol was administered to them at the end of the 9th week. According to the different dose of the drug,they were defined as model group（no drug）,low dose group（15 g crude drug/kg）,middle dose group（30 g crude drug/kg）,and high dose group（45 g crude drug/kg）. Then they were killed at the end of the 12th week,and the validity of the model was tested by immunofluorescence staining. The expression levels of IL-13,IL-5 and IL-4 renal tissues were detected by RT-PCR,and the CIC concentration of serum was measured by ELISA. Results showed that the experimental model was successful. In contrast to the normal group,the relative expression levels of IL-4,IL-5 and IL-13 in the model group were significantly higher（P < 0.001）. Compared with the model group,the relative expression levels of IL-4,IL-5,and IL-13 in the low,middle and high dose groups decreased gradually,and the comparison of the cytokine indexes between every two groups had statistical significance（P < 0.01）. Compared with the normal group,the CIC concentration from serum in the model group was significantly higher（P < 0.01）,and those in the low,medium and high dose groups were higher than the normal group,but there was no significant statistical significance when compared with the normal group（P > 0.05）;moreover,they showed a gradually decreasing trend in comparison with the model group and they were significantly lower（P < 0.05）. In summary,resveratrol significantly down-regulates the expressions of total pro-inflammatory factor IL-5 in the renal tissues of IgA rats,and the anti-inflammatory factors IL-4 and IL-13 decrease their values after the inflammatory reaction decreased. Besides,resveratrol also significantly reduce the CIC concentration of serum in IgA rats.

Key words: resveratrol, IgA nephropathy, TH2 inflammatory factor, circulating immunocomplex