Applications of Synthetic Biology in the Research of Natural Product

doi:10.13560/j.cnki.biotech.bull.1985.2017.01.004

Abstract

Abstract: As an important source of clinical medicine and new drug candidate,natural product plays an essential role in therapeutic and pharmaceutical industry. However,traditional methods for natural product discovery constrain the development of new compounds at certain extent,and identifying and refactoring the biosynthetic pathways of natural products provided new thoughts for the discovery of new natural product. Currently,with the prosperous development of bioinformatics and synthetic biology technologies,a new era of natural product discovery and engineering can be foreseen. Here,we summarize recent advances on the strategies of genetic recombination and gene cluster regulation related to synthetic biology techniques,and discuss their applications and issues in studying natural products.

Key words: natural product, synthetic biology, genetic recombination, gene editing, chassis design, heterologous expression, CRISPR/Cas9

WANG Li-ping, LUO Yun-zi. Applications of Synthetic Biology in the Research of Natural Product[J]. Biotechnology Bulletin, 2017, 33(1): 35-47.

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