Bacterail Pathogens Resistance to Phages During the Phage Therapy

Abstract

Abstract: Bacterial pathogens have been treated effectively with antibiotics for several decades, but with more and more resistant bacteria appeared, the resistance to antibiotics has become a difficulty issue in antibiotics therapies. Phages therapy, the application of the phages that infect bacterial pathogens as antimicrobials, has been expected and advocated as a promising alternative to conventional antibiotics. However, under the selection of the co-evolution between phages and bacteria, bacterial pathogens can became resistance to the phages by several mechanisms. So, at the same expecting and advocating, should we worry about the problem that whether the phage-treated pathogens will develop to resistance to the phages caused to treat difficulty at last? Here, the arguments about the bacterial pathogens resistance to the phages under the phage-bacterium co-evolution and its effect on the phages therapy were summarized and reviewed, and the phage therapy for control the bacterial pathogen was prospected.

Key words: Bacterium, Phage, Phage therapy, Resistance, Co-evolution

Cai Liuti, Chen Xingjiang, Liu Yanxia, Shi Junxiong. Bacterail Pathogens Resistance to Phages During the Phage Therapy[J]. Biotechnology Bulletin, 2014, 0(7): 33-36.

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