The Protective Effect of Haworth Fruit Extract on Caenorhabditis elegans in Acute Damages

doi:10.13560/j.cnki.biotech.bull.1985.2016.04.035

Abstract

Abstract: The work aims to study the protective effect of haworth fruit extract（HFE）on the acute oxidative damage and its possible protection mechanism in Caenorhabditis elegans. The C. elegans were fed with nematode growth medium（NGM）containing different dose of HFE（0，25，50 and 100 μg/mL）to study impacts of HFE on the acute stress tolerance. C. elegans with feeding in different dose of HFE had a longer lifespan than the normal group，moreover，their lifespans became significantly longer under the experiments of juglone oxidative stress，heat stress and UV radiation stress. Concurrently，the autofluorescence level of lipofuscin in HFE group of C. elegans significantly decreased and it was dose-dependent effect to the concentration of HFE. In conclusion，HFE significantly prolongs the lifespan of C. elegans and has a solid protection under a variety of oxidative stress conditions with improving the antioxidant capacity and efficient anti-aging

Key words: Caenorhabditis elegans, extract of haworth fruit, acute damage, anti-aging

ZHAO Jiang, CHEN Chun, WANG Yi-fei， ,WANG Hong， ,HUANG Jie， ,WANG Hao. The Protective Effect of Haworth Fruit Extract on Caenorhabditis elegans in Acute Damages[J]. Biotechnology Bulletin, 2016, 32(4): 256-260.

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