Effects of Nano-TiO2 and Tetracycline Exposure on Drug-resistant Escherichia coli

doi:10.13560/j.cnki.biotech.bull.1985.2019-0528

Abstract

Abstract: The drug-resistant Escherichia coli（M13）and sensitive quality control strain（E. coli ATCC25922）were used to study the effects of nano-TiO₂ and tetracycline on the growth of E. coli. The results showed that the addition of nano-TiO₂further inhibited the growth of sensitive bacteria compared with the addition of the gradient concentration of tetracycline alone,while the drug-resistant bacteria did not change much. The antibacterial rate of nano-TiO₂ alone or co-exposure to the drug-resistant bacteria was below 40%,while that to the sensitive bacteria ranged in 80% and 100%. The drug-resistant strain M13 was resistant to antibiotics and also to nano-TiO₂.There are some commonalities between microbial resistance mechanisms against antibiotics and other environmental virulence factors,but the mechanism of microbial resistance under co-exposure conditions remains to be further studied.

Key words: drug-resistant Escherichia coli, nano-TiO₂, tetracycline, antibacterial rate

ZHANG Yong-li, YUAN Wei, YANG Qing-xiang. Effects of Nano-TiO₂ and Tetracycline Exposure on Drug-resistant Escherichia coli[J]. Biotechnology Bulletin, 2019, 35(11): 124-131.

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Effects of Nano-TiO₂ and Tetracycline Exposure on Drug-resistant Escherichia coli

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