Role of Gut-Liver Axis in Animal Nutritional Metabolism and Immunity

doi:10.13560/j.cnki.biotech.bull.1985.2021-1322

Abstract

Abstract:

The gut-liver axis is a bidirectional relationship between intestinal microorganisms and the liver,which is essential for the intestinal microbe to affect the host. Growing studies have shown that the gut-liver axis plays a key regulatory role in animal nutrition metabolism and body immunity. Based on the bridge role of the gut-liver axis in the interaction between intestinal microbe and host,this review discusses two regulatory mechanisms of gut-liver axis in animal nutrition metabolism and body immunity：endocannabinoid system and gut microbiota-derived signals. Gut microbiota-derived signals include short-chain fatty acids,bile acids,choline metabolites,amino acid metabolites,and microbial-related molecular patterns. Finally,the paper discusses application prospect of gut-liver axis theory in animal husbandry production,aiming to provide support for healthy and efficient animal feeding without antibiotics.

Key words: gut-liver axis, nutritional immunity, the endocannabinoid system, short-chain fatty acids, bile acids, microbial-related molecular patterns

JIANG Xian-zhe, ZHANG Bo-yan, LUO Hai-ling, ZHANG Xin-meng, WANG Bing. Role of Gut-Liver Axis in Animal Nutritional Metabolism and Immunity[J]. Biotechnology Bulletin, 2022, 38(7): 128-135.

Figures/Tables 1

References 58

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