Related Inflammatory Diseases Caused by Mitochondrial Dysfunction and Targeted Therapy to Them

doi:10.13560/j.cnki.biotech.bull.1985.2022-1146

Abstract

Abstract:

As an essential organelle in eukaryotic cells, mitochondria play a central role in energy metabolism, maintenance of redox balance and regulation of apoptosis. Mitochondrial dysfunction, whether caused by mitochondrial damage, mitochondrial DNA gene mutation or defective mitochondrial electron transport chain, oxidative stress, or abnormal genes and inflammatory signal transduction, will cause certain damages to tissues or organs or lead to inflammation, such as kidney, liver, breast and other organs or tissues. This paper summarized the functions of important components in mitochondria, including mitochondrial DNA, cytochrome c and cardiolipin, and the inflammatory diseases caused by mitochondrial dysfunction, as well as the treatment of mitochondrial dysfunction, aiming to provide more technical support for mitochondrial dysfunction, inflammatory diseases and targeted therapy.

Key words: mitochondrial dysfunction, inflammatory diseases

MA Xue-hu, MA Li-hua, GOU Yan, MA Yan-fen. Related Inflammatory Diseases Caused by Mitochondrial Dysfunction and Targeted Therapy to Them[J]. Biotechnology Bulletin, 2023, 39(6): 119-125.

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