Polyamine Metabolism and Signaling Transduction in Tumor Cells

Abstract

Abstract: The rapid growth of tumor cells depends on their higher intracellular polyamine levels compared to normal cells. Depletion of intracellular polyamine could inhibit tumor cells’proliferation and induce tumor cells apoptosis. It is worth noting that, the alteration of the intracellular polyamine concentration have an obvious effect on multiple cell signal transduct in tumor cells. Because of the functional diversity and complexity of cell signalling molecules, the regulation of these signaling pathways activity result in both activated or suppressive effect on tumor cell survival, differentiation, migration and invasion. This article summarized the effects of polyamines metabolism on tumor-associated signalling pathways and the underlying molecular mechanism.

Key words: Polyamine metabolism, Signalling transduct, Tumor

Wang Qing, Wang Yanlin, Cao Chunyu. Polyamine Metabolism and Signaling Transduction in Tumor Cells[J]. Biotechnology Bulletin, 2014, 0(1): 58-62.

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