Biotechnology Bulletin ›› 2016, Vol. 32 ›› Issue (1): 195-200.doi: 10.13560/j.cnki.biotech.bull.1985.2016.01.031

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Isolation and Identification of a Deep-sea-derived Fungus FS86 and Its Biological Activities

WU Hou-lv1, 2, LI Hao-hua2, TAN Guo-hui2, CHEN Yu-chan2, LIU Yun-mei1, ZHANG Wei-min2   

  1. 1. Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001;
    2. State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070
  • Received:2015-05-08 Online:2016-01-09 Published:2016-01-22

Abstract: A strain of fungus FS86 was isolated from deep-sea sediment of South China Sea by the spread plate method. According to the culture features, morphological characteristics and ITS sequence analysis, the strain was identified as Cladosporium sphaerospermum. Bioassay results showed that the fermentation extract of the strain FS86 demonstrated significant inhibitory effects against 8 pathogenic fungi and 4 tumor cell lines with MICs of 0.1-4 mg/mL and IC50 values of 0.86-2.13 μg/mL, respectively.

Key words: deep sea fungus, Cladosporium sphaerospermum, isolation, identification, antifungal, cytotoxic