Research Progress on Epigenetic Regulation Mechanism in the Differentiation of Bone Marrow Mesenchymal Stem Cell

doi:10.13560/j.cnki.biotech.bull.1985.2016.07.003

Abstract

Abstract: Bone Marrow Mesenchymal Stem Cells（BMMSCs）,with the potential of self-renewal and multipotent differentiation,may differentiate to be several types of cells by induction,thus hold critical clinic values for the restoration of destroyed bones and cartilages. In order to investigate a medicine that may efficiently promote the directional differentiation of BMMSCs and thus using BMMSCs in clinic more safely and reasonably,it is necessary to illustrate the epigenetic regulation mechanism in the differentiation process of BMMSCs. Abnormal regulation of BMMSCs differentiation may lead to development of several diseases,thus appropriate control of BMMSCs differentiation mechanism has been the hotspot topic of research. Epigenetic regulation,such as DNA methylation,histone acetylation,histone methylation and noncoding RNA,play critical roles in the regulation of BMMSCs differentiation. This review summarizes the progress on major epigenetic regulation mechanisms involved in BMMSCs differentiation in recent years.

Key words: bone marrow mesenchymal stem cells（BMMSCs）, cell differentiation, epigenetic regulation

WANG Lian-qing ZHAI Qiao-li ZHAO Pei-qing LI Tao. Research Progress on Epigenetic Regulation Mechanism in the Differentiation of Bone Marrow Mesenchymal Stem Cell[J]. Biotechnology Bulletin, 2016, 32(7): 21-27.

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