Research Progress on the Synthesis of S-adenosyl-L-methionine in Microorganism

doi:10.13560/j.cnki.biotech.bull.1985.2017.01.010

Abstract

Abstract: S-adenosyl-L-methionine（SAM）as an important metabolite exists in all cell types of living organisms,presents promising effects on liver diseases and depressive syndromes without any side effects,thus,it is greatly demanded in medical market. Recently,broad studies on biosynthesis of SAM have been conducted by scholars in the world. On the one hand,fermentation strategies based on traditionally producing SAM were further improved;on the other hand,different rational breeding programs were developed,such as fine tuning host’s metabolic network or screening strains by synthetic gene circuit. In this paper,progress in the research of S-adenosyl-L-methionine production is summarized,and the significances and issues while efficiently producing SAM by microorganism are discussed,aiming at providing the guides for improving SAM productivity at an industrial scale.

Key words: S-adenosyl-L-methionine, yeast, synthetic gene circuit, fermentation, metabolic engineering

ZHAO Wei-jun, HUANG Lei, XU Zhi-nan. Research Progress on the Synthesis of S-adenosyl-L-methionine in Microorganism[J]. Biotechnology Bulletin, 2017, 33(1): 99-105.

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