Drug Research in Cancer Therapy Based on Polyamine Transport System

doi:10.13560/j.cnki.biotech.bull.1985.2017.05.005

Abstract

Abstract: Polyamine is an essential substance in cells growth,differentiation and other life activities. The proliferation of tumor is closely related to the level of intracellular polyamine. Delivering polyamine analogs and conjugates into cells,mediated by polyamine transport system overexpressed on tumor cell surface,leads to the exhaustion of intracellular polyamine and then induces tumor cells apoptosis. In addition,using the positive structure characteristics of polyamine to deliver therapeutic genes may increase the transfection efficiency of exogenous genes. In order to provide reference for the research of anticancer agents based on polyamine in the future,the research progress on polyamine analogues and conjugates for treating cancer and using polyamine as a gene deliver vector are summarized here.

Key words: polyamine transport system, polyamine analogues, polyamine conjugates, tumor targeting, gene delivery

LI Jian-ming DING Jin-song. Drug Research in Cancer Therapy Based on Polyamine Transport System[J]. Biotechnology Bulletin, 2017, 33(5): 34-39.

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