Study Advance on Polymer and Phosphatidylcholine Nano-micelles Drug Delivery System

doi:10.13560/j.cnki.biotech.bull.1985.2016-1084

Abstract

Abstract: In clinical practice,the poorly water-soluble drugs will not only seriously affect the therapeutic effect,but also may cause a series of toxic side-effects,therefore,delivery system for a poorly water-soluble drug has become a research hotpot. Nano-micelles system is one of the most effective drug delivery systems,which mainly consists of the hydrophilic shell and hydrophobic core. Nano-micelles as a nano-size drug delivery system presents many unique advantages,such as can effectively avoid the early-release of drug in blood circulation,reduce toxic side-effects and improve targeting,further increase the utilization of poorly soluble drug by organisms,etc.,showing promising application prospect in drug delivery system for a poorly soluble drug. This review describes the category,constitute,characterization and its toxicity and pharmacokinetics detection application of polymer and phosphatidylcholine nano-micelles.

Key words: nano-micelle, drug delivery system, pharmacokinetic

LI Ya-zi, XU Shu-jing. Study Advance on Polymer and Phosphatidylcholine Nano-micelles Drug Delivery System[J]. Biotechnology Bulletin, 2017, 33(6): 32-38.

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