Research Progress on Genetic Diversity of Shiraia bambusicola,Biosynthesis and Anticancer Activity of Hypocrellin

doi:10.13560/j.cnki.biotech.bull.1985.2018-0116

Abstract

Abstract: Shiraia bambusicola is an important species of medicinal fungi in China. Its major active metabolites are perylenequinone pigment,such as hypocrellin. The former researches on S. bambusicola were mainly focused on the analysis of active products,clinical application,and biological fermentation,etc. The genetic diversity of S. bambusicola results in the differences of hypocrellin anabolism among different populations and strains. With the antitumor mechanism of hypocrellin and derivatives continuously discovered,studies on the genetic diversity of S. bambusicola,the synthesis and metabolism and anticancer mechanism of hypocrellin are proceeding more deeply. Applying different molecular markers reveal that the genetic diversity of S. bambusicola might be mainly from a population or among populations. Moreover,hypocrellin presents a promising prospect in the photodynamic therapy（PDT）of tumor by chemical modification or physical modification. Meanwhile,new results of research on the polyketide synthase genes and other genes,which affect the production of hypocrellin,will eventually help to reveal the biosynthesis pathway of hypocrellin in S. bambusicola. This article reviews the research progress on the genetic diversity of S. bambusicola and the role of hypocrellin and derivatives on cancer cells,the biosynthesis of hypocrellin,aiming at providing valuable references for the conservation of S. bambusicola,the further research and development of hypocrellin.

Key words: Shiraia bambusicola, hypocrellin, genetic diversity, antitumor activity, biosynthesis

ZHAO Ning, CHEN Shuang-lin. Research Progress on Genetic Diversity of Shiraia bambusicola,Biosynthesis and Anticancer Activity of Hypocrellin[J]. Biotechnology Bulletin, 2018, 34(4): 16-23.

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