Abstract: The antitumor activities of water extracts from 6 “Sanghuang” fungi were studied with H₂₂ mice in vivo. The results showed that the high and low dose groups of the water extracts from Inonotus hispidus,Fomitiporia ellipsoidea,and Phellinus yamanoi and high dose group of the water extracts from Phellinus igniarius,Phellinus baumii,and Phellinus vaninii presented significant antitumor effect with over 40% of antitumor rate,except the low dose group of it from P. baumii. Among them,the antitumor effect of the water extract from F. ellipsoidea（1000 mg/kg）was the best. Compared with positive and control group,the thymus index of the tested mice in the high dose group of water extract from I. hispidus showed a very significant difference（P < 0.01）,but ones in the other groups had not. The water extracts from 6 “Sanghuang” fungi all can promote the expression of Bax in mouse tumor cells,and inhibit the expression of Bcl-2.

Key words: Sanghuang, Inonotus hispidus, Phellinus igniarius, Fomitiporia ellipsoidea, antitumor