Research Progress on the Effects of T3SS Effectors on Apoptosis and Pyroptosis of Host Cells

doi:10.13560/j.cnki.biotech.bull.1985.2018-0897

Abstract

Abstract: Pathogenic bacterial infection causes a serious threat to human health. Pathogens that harbor a Type III Secretion System（T3SS）can inject effectors into host cells through T3SS and manipulate multiple signaling pathways,thereby facilitating the proliferation and dissemination of pathogens. T3SS effectors play important roles in the signaling pathways involved in apoptosis and pyroptosis of host cells. The effects of T3SS effectors on host have been widely investigated,the effectors of different pathogens exert similarly or differently functions,and the effectors of one species exhibit synergistic or antagonistic roles. Here,we reviewed the latest researches on the function and mechanism of T3SS effectors involved in cell apoptosis and pyroptosis,and made a summary and analysis. It aims to provide references and insight for intensively researching it,thus promoting research on the mechanism of pathogenic bacteria and providing theoretical basis of prevention and treatment of pathogens.

Key words: type III secretion system, effectors, apoptosis, pyroptosis

ZHU Ping, DU Li-jie, MENG Kun, XUE Juan, YANG Jin, LI Shan. Research Progress on the Effects of T3SS Effectors on Apoptosis and Pyroptosis of Host Cells[J]. Biotechnology Bulletin, 2019, 35(4): 178-187.

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