Effects of Inflammation and Tumorigenesis on the Imbalance of Hematopoietic Progenitor Cells

doi:10.13560/j.cnki.biotech.bull.1985.2018-1008

Abstract

Abstract: This article mainly investigates the effects of inflammation and tumors on hematopoietic progenitor cells（HPCs）in the hematopoietic-immune system of mice,and explores the correlation between hematopoietic-immune lines in inflammation and tumor status. AOM（Azoxymethane）and DSS（Dextran sulfate sodium salt）were used to induce the mouse model of inflammatory colon cancer,and flow cytometry was used to the abundance and cell cycle of hematopoietic progenitor cells in normal,inflammatory and tumor mice. In the process of inflammation and tumor progression,the percentage of multi-potent progenitors（MPPs）in the bone marrow of mice significantly increased,and common myeloid progenitors（CMPs）and megakaryocytes/megakaryocyte/erythrocyte progenitors（MEPs）and granulocyte/macrophage progenitors（GMPs）demonstrated similar changes,whereas common lymphoid progenitors（CLPs）decreased significantly. Moreover,in the inflammatory and tumor states,the division ability of myeloid progenitor cell was significantly stronger than the normal physiological state. In addition,the tumor peripheral blood CD4⁺/CD8⁺ T cell ratio decreased significantly in the tumor state. In the process of inflammation and tumor progression,HSPCs were biased toward myeloid differentiation. In the tumor state,the cellular immune function of mice was unbalanced;in addition,long-term inflammatory damage may cause imbalance of the immune system and eventually lead to tumor formation.

Key words: inflammatory, tumor, immune system, immune function

LI Xiao-yu, LIU Lin, XING Bing, TANG Jing, LIU Ya-ping, ZHOU Zu-ping, PU Shi-ming. Effects of Inflammation and Tumorigenesis on the Imbalance of Hematopoietic Progenitor Cells[J]. Biotechnology Bulletin, 2019, 35(8): 155-161.

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