The Relationship Between Lung Microbiota and Respiratory Diseases

doi:10.13560/j.cnki.biotech.bull.1985.2019-0905

Abstract

Abstract: The respiratory tract mucosal immune system has good defensive and protective effects against invaded pathogens and strong eliminating ability,therefore the lungs of healthy organisms are considered sterile for a long time. With the development of the culture-independent sequencing technology,studies on the composition structure and immune regulating functions of lung microbiota are much focused. Early life development and maturation of respiratory microbiota are shaped by birth mode,diet structure,living environment and antibiotic expose,and the formation and development of lung microbiota in early life might affect the occurrence and development of respiratory diseases throughout the life cycle. The interactions among lung microbiota,host immune system,intestinal microbiota and respiratory viruses can regulate the immune homeostasis and inflammatory infection of the lung. Therefore,early life intervention of lung microbiota communities can be explored as an effective strategy and novel target to prevent and control respiratory diseases.

Key words: lung microbiota, immunity homeostasis, inflammatory response, respiratory disease

LI Zong-jie, DI Di, LI Bei-bei. The Relationship Between Lung Microbiota and Respiratory Diseases[J]. Biotechnology Bulletin, 2020, 36(2): 188-192.

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