Research Advances on Transcription Factor Yrr1p of Pleiotropic Drug Resistance in Saccharomyces cerevisiae

doi:10.13560/j.cnki.biotech.bull.1985.2020-0401

Abstract

Abstract:

Yrr1p（for yeast reveromycin A resistance）is a zinc finger transcription factor involved in the pleiotropic drug resistance（PDR）,and plays important role in the drug resistance and inhibitor resistance of Saccharomyces cerevisiae. This paper reviewed the discovery process of Yrr1p,the relationship between Yrr1p structure and function,and the mechanism of resistances mediated by Yrr1p in S. cerevisiae to different inhibitors of 4-nitroquinoline-N-oxide,salicylic acid,mancozeb,and vanillin. Tolerance mechanism to vanillin stress mediated by Yrr1p displayed remarkable differences from other drugs. Further the paper outlined the regulatory relationship between Yrr1p and its homologous transcription factors Yrm1p,Pdr8p,and its upstream regulatory factors Pdr1p,Pdr3p. The research of Yrr1p provides scientific guidance for studying microbial tolerance and constructing highly resistant microbial cell factories.

Key words: Yrr1p, transcription factor, tolerance, Saccharomyces cerevisiae

CAO Wen-yan, WANG Xin-ning, SHEN Yu, LI Zai-lu, BAO Xiao-ming. Research Advances on Transcription Factor Yrr1p of Pleiotropic Drug Resistance in Saccharomyces cerevisiae[J]. Biotechnology Bulletin, 2020, 36(11): 148-154.

Figures/Tables 3

References 28

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