Rapid Screening Strategy for Target Identification of Bioactive Natural Products

doi:10.13560/j.cnki.biotech.bull.1985.2020-0400

Abstract

Abstract:

Bioactive natural products from traditional Chinese medicine and other natural resources are the important origin of medicines. Identification of the protein target in bioactive natural products is the key step to clarify the pharmacology and toxicology of them and prepared medicines. The current traditional target screening method is based on the molecular marker tracing,which has a long cycle and also leads to changes in the structure and pharmacological effect of natural products,and thus it has drawbacks. The novel coronavirus diseases（Coronavirus Disease 2019,COVID-19）enlightens us：It is of great value to reveal the target of drug action for the promotion and application of natural products. In recent years,the rapid screening technology for the pharmacological targets of unlabeled natural products based on the protein physical and chemical properties and omics is maturing. In this article,we sort and summarize the major unlabeled and rapid screening strategies for the protein targets of natural products via the practical cases,and aim to provide a prospective reference for the practioners in this field.

Key words: bioactive natural products, protein target, molecular pharmacology

CHEN Peng. Rapid Screening Strategy for Target Identification of Bioactive Natural Products[J]. Biotechnology Bulletin, 2020, 36(11): 180-187.

Figures/Tables 1

References 70

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