Research Progress in Antibiotic Adjuvant and Antibiotics in Antibacterial Aspects

doi:10.13560/j.cnki.biotech.bull.1985.2022-0027

Abstract

Abstract:

Antimicrobial resistance has been a global health challenge,which increases the difficulty of controlling and treating life-threatening bacterial infections. Despite ongoing efforts to identify new drugs or alternatives to antibiotics,no new classes of antibiotic or their alternatives have been clinically approved in the last two decades. A combination of antibiotic adjuvants and antibiotics inhibit bacterial resistance determinants or restore antibiotic sensitivity,and offer a sustainable and effective strategy to combat multidrug-resistant bacteria. The current review summarizes the classification and mechanism of antibiotic adjuvants,as well as discusses the challenges and development trends of antibiotic adjuvant and antibiotic combination strategy.

Key words: antimicrobial synergist, antibiotics, drug resistance, synergistic effect

ZHU Hao, ZHANG Yan-wei, LIU Run, LIANG Yan, YANG Yi, XU Tian-le, YANG Zhang-ping. Research Progress in Antibiotic Adjuvant and Antibiotics in Antibacterial Aspects[J]. Biotechnology Bulletin, 2022, 38(6): 66-73.

Figures/Tables 1

References 63

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