Abstract: DNA methylation is one of the important epigenetic mechanisms in eukaryotes. In recent years, more attention was paid upon genome-wide DNA methylation in plant and animal genetics and breeding. The ability to access the methylation status for a large number of genes or the entire genome should greatly facilitate the understanding of the nature of gene regulation in cells, and epigenetic mechanism of interactions between cells and environment. This paper summarized some important aspects of DNA methylation profiles, DNA methylation profiling technologies and the progresses of DNA methylation profiles including animal. Finally, prospect of DNA methylation profiles is given a brief discussion.