基于铂纳米团簇的生物传感研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2021-0247

摘要/Abstract

摘要：

在过去的几十年中,金和银纳米簇（gold and silver nanoclusters,Au NCs and Ag NCs）得到了广泛的探索,并用于工业催化、光电器件、生物成像、环境测试、临床诊断和治疗领域。同样作为贵金属团簇,有关铂纳米簇（platinum metal nanoclusters,Pt NCs）的生物传感应用讨论相对较少。Pt NCs具有出色的反应活性、光学特性、催化活性、导电性和生物相容性,并且已被证明可用于生物传感和医学成像。鉴于上述出色的性能,我们从合成和特有性质的角度总结了Pt NCs,并总结了它们在传感和成像中的生物学应用。

关键词: 铂纳米簇, 荧光, 催化, 生物传感器

Abstract:

In the past few decades,gold and silver nanoclusters（Au NCs and Ag NCs）have been extensively explored and used in industrial catalysis,optoelectronic devices,biological imaging,environmental testing,clinical diagnosis and treatment. However,as precious metal clusters,there is relatively little discussion about the biosensing application of platinum nanoclusters（Pt NCs）. Pt NCs are of excellent reactivity,optical properties,catalytic activity,electrical conductivity and biocompatibility,and has been proven to be used in biosensing and medical imaging. In view of the above-mentioned excellent performance,we summarized Pt NCs from the perspective of synthesis and unique properties,and outlined their biological applications in sensing and imaging.

Key words: platinum nanoclusters, fluorescence, catalysis, biosensors

王鹏飞, 杨敏, 朱龙佼, 许文涛. 基于铂纳米团簇的生物传感研究进展[J]. 生物技术通报, 2021, 37(12): 235-242.

WANG Peng-fei, YANG Min, ZHU Long-jiao, XU Wen-tao. Advances in Biosensors Based on Platinum Nanoclusters[J]. Biotechnology Bulletin, 2021, 37(12): 235-242.

图/表 1

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配体 Ligand	发射波长 Emission wavelength/nm	颜色 Colour	量子产率 Quantum yield/%	参考文献 Reference
BSA	350-500	蓝色	/	[11]
N,N-二甲基甲酰胺（DMF）	484、544	青色、绿色	/	[32]
PAMAM（G4-OH）	470、520	蓝色、绿色	18、28	[33-34]
聚乙烯亚胺（PEI）	465、530、560	蓝色、绿色、黄色	4、11、7	[31]
谷胱甘肽（GSH）	570	黄色	17	[35]
硫辛酸（LA）	680	红色	47	[36]
血红蛋白（HGB）	450、760	蓝色、红色	/	[37]

配体 Ligand	发射波长 Emission wavelength/nm	颜色 Colour	量子产率 Quantum yield/%	参考文献 Reference
BSA	350-500	蓝色	/	[11]
N,N-二甲基甲酰胺（DMF）	484、544	青色、绿色	/	[32]
PAMAM（G4-OH）	470、520	蓝色、绿色	18、28	[33-34]
聚乙烯亚胺（PEI）	465、530、560	蓝色、绿色、黄色	4、11、7	[31]
谷胱甘肽（GSH）	570	黄色	17	[35]
硫辛酸（LA）	680	红色	47	[36]
血红蛋白（HGB）	450、760	蓝色、红色	/	[37]