Progress on Antiviral Agents Against African Swine Fever Virus

doi:10.13560/j.cnki.biotech.bull.1985.2020-1079

Abstract

Abstract:

African swine fever（ASF）,the most serious exotic pig disease,is listed as a class Ⅰ animal disease in China. The continuous infection since the outbreak of ASF in Shenyang on August 2018 is now ravaging the development of China’s pork industry,seriously threating the healthy development of pig breeding. There is no commercialized vaccine or cost-effective antiviral drugs,thus only quick killing is reliable to control the disease once pigs are infected. This review summarized the recent research status of agents including interferons,antibiotics,nucleoside analogues,plant-derived products and other compounds that have been reported to inhibit ASFV replication,aiming to provide theoretical basis and reference for the development of potential anti-ASFV drugs.

Key words: African swine fever virus, antiviral agents, interferons, nucleoside analogues, plant-derived products

ZHAO Hong-yuan, WANG Zhao, CHENG Wen-yu, MA Ning-ning, LI Man, WEI Xiao-li. Progress on Antiviral Agents Against African Swine Fever Virus[J]. Biotechnology Bulletin, 2021, 37(5): 174-181.

References 43

[1]	张睿, 黄旖童, 鲍晨沂, 等. 非洲猪瘟流行病学及其在中国扩散的因素分析[J]. 病毒学报, 2019,35(3):512-522.
	Zhang R, Huang YT, Bao CY, et al. Epidemiology of African swine fever and analysis of risk factors of its spread in China:An overview[J]. Chinese J Virol, 2019,35(3):512-522.
[2]	欧云文, 刘俐君, 代军飞, 等. 非洲猪瘟病毒结构蛋白在病毒感染过程中的作用[J]. 生物技术通报, 2019,35(6):156-163.
	Ou YW, Liu LJ, Dai JF, et al. Roles of African swine fever virus structural proteins in viral infection[J]. Biotech Bulletin, 2019,35(6):156-163.
[3]	Hurtado C, Bustos MJ, Carrascosa AL. The use of COS-1 cells for studies of field and laboratory African swine fever virus samples[J]. J Virol Methods, 2010,164(1-2):131-134. doi: 10.1016/j.jviromet.2009.11.030 URL
[4]	de León P, Bustos MJ, Carrascosa AL. Laboratory methods to study African swine fever virus[J]. Virus Res, 2013,173(1):168-179. doi: 10.1016/j.virusres.2012.09.013 URL
[5]	Portugal R, Goatley LC, Husmann R, et al. A porcine macrophage cell line that supports high levels of replication of OURT88/3, an attenuated strain of African swine fever virus[J]. Emerg Microbes Infect, 2020,9(1):1245-1253. doi: 10.1080/22221751.2020.1772675 URL
[6]	Gaudreault NN, Madden DW, Wilson WC, et al. African swine fever virus:an emerging DNA arbovirus[J]. Front Vet Sci, 2020,7:215. doi: 10.3389/fvets.2020.00215 pmid: 32478103
[7]	Revilla Y, Pérez-Núñez D, Richt JA. African swine fever virus biology and vaccine approaches[J]. Adv Virus Res, 2018,100:41-74.
[8]	Lee AJ, Ashkar AA. The dual nature of type I and type II interferons[J]. Front Immunol, 2018,9:2061. doi: 10.3389/fimmu.2018.02061 URL
[9]	Schoggins JW. Interferon-stimulated genes:what do they all do?[J] Annu Rev Virol, 2019,6(1):567-584. doi: 10.1146/annurev-virology-092818-015756 pmid: 31283436
[10]	Arabyan E, Kotsynyan A, Hakobyan A, et al. Antiviral agents against African swine fever virus[J]. Virus Res, 2019,270:197669. doi: 10.1016/j.virusres.2019.197669 URL
[11]	Paez E, Garcia F, Gil Fernandez C. Interferon cures cells lytically and persistently infected with African swine fever virus in vitro[J]. Arch Virol, 1990,112(1-2):115-1127. pmid: 1695091
[12]	Fan W, Jiao P, Zhang H, et al. Inhibition of African swine fever virus replication by porcine type I and type II interferons[J]. Front Microbiol, 2020,11:1203. doi: 10.3389/fmicb.2020.01203 URL
[13]	Netherton CL, Simpson J, Haller O, et al. Inhibition of a large double-stranded DNA virus by MxA protein[J]. J Virol, 2009,83(5):2310-2320. doi: 10.1128/JVI.00781-08 URL
[14]	Muñoz-Moreno R, Cuesta-Geijo MÁ, Martínez-Romero C, et al. Antiviral role of IFITM proteins in African swine fever virus infection[J]. PLoS One, 2016,11(4):e0154366. doi: 10.1371/journal.pone.0154366 URL
[15]	Galindo I, Cuesta-Geijo MÁ, Del Puerto A, et al. Lipid exchange factors at membrane contact sites in African swine fever virus infection[J]. Viruses, 2019,11(3):199. doi: 10.3390/v11030199 URL
[16]	孙茂文, 王涛, 孙元, 等. 非洲猪瘟病毒的免疫逃逸策略[J]. 微生物学报, 2020. DOI: https://DOI.org/10.13343/j.cnki.wsxb.20200166.
	Sun MW, Wang T, Sun Y, et al. Immunoevasion strategies of African swine fever virus[J]. Acta Microbiologica Sinica, 2020. DOI: https://doi.org/10.13343/j.cnki.wsxb.20200166.
[17]	Garriga D, Headey S, Accurso C, et al. Structural basis for the inhibition of poxvirus assembly by the antibiotic rifampicin[J]. Proc Natl Acad Sci U S A, 2018,115(33):8424-8429. doi: 10.1073/pnas.1810398115 URL
[18]	Coelho J, Ferreira F, Martins C, et al. Functional characterization and inhibition of the type II DNA topoisomerase coded by African swine fever virus[J]. Virology, 2016,493:209-216. doi: 10.1016/j.virol.2016.03.023 URL
[19]	Coelho J, Leitão A. The African swine fever virus(ASFV)topoisomerase II as a target for viral prevention and control[J]. Vaccines(Basel), 2020,8(2):312.
[20]	Mottola C, Freitas FB, Simões M, et al. In vitro antiviral activity of fluoroquinolones against African swine fever virus[J]. Vet Microbiol, 2013,165(1-2):86-94. doi: 10.1016/j.vetmic.2013.01.018 URL
[21]	de León P, Bustos MJ, Torres E, et al. Inhibition of porcine viruses by different cell-targeted antiviral drugs[J]. Front Microbiol, 2019,10:1853. doi: 10.3389/fmicb.2019.01853 URL
[22]	Gil-Fernández C, Páez E, Vilas P, et al. Effect of disodium phosphonoacetate and iododeoxyuridine on the multiplication of African swine fever virus in vitro[J]. Chemotherapy, 1979,25(3):162-169. doi: 10.1159/000237836 URL
[23]	Arzuza O, García-Villalón D, Tabarés E, et al. Inhibition of African swine fever virus DNA synjournal by(S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine[J]. Biochem Biophys Res Commun, 1988,154(1):27-32. doi: 10.1016/0006-291X(88)90644-4 URL
[24]	Parrish S, Hurchalla M, Liu SW, et al. The African swine fever virus g5R protein possesses mRNA decapping activity[J]. Virology, 2009,393(1):177-182. doi: 10.1016/j.virol.2009.07.026 URL
[25]	Villalón MD, Gil-Fernández C, De Clercq E. Activity of several S-adenosylhomocysteine hydrolase inhibitors against African swine fever virus replication in Vero cells[J]. Antiviral Res, 1993,20(2):131-144.
[26]	St Vincent MR, Colpitts CC, Ustinov AV, et al. Rigid amphipathic fusion inhibitors, small molecule antiviral compounds against enveloped viruses[J]. Proc Natl Acad Sci U S A, 2010,107(40):17339-17344. doi: 10.1073/pnas.1010026107 URL
[27]	Hakobyan A, Galindo I, Nañez A, et al. Rigid amphipathic fusion inhibitors demonstrate antiviral activity against African swine fever virus[J]. J Gen Virol, 2018,99(1):148-156. doi: 10.1099/jgv.0.000991 URL
[28]	Hakobyan A, Arabyan E, Avetisyan A, et al. Apigenin inhibits African swine fever virus infection in vitro[J]. Arch Virol, 2016,161(12):3445-3453. doi: 10.1007/s00705-016-3061-y URL
[29]	Hakobyan A, Arabyan E, Kotsinyan A, et al. Inhibition of African swine fever virus infection by genkwanin[J]. Antiviral Res, 2019,167:78-82. doi: 10.1016/j.antiviral.2019.04.008 URL
[30]	Arabyan E, Hakobyan A, Kotsinyan A, et al. Genistein inhibits African swine fever virus replication in vitro by disrupting viral DNA synjournal[J]. Antiviral Res, 2018,156:128-137. doi: 10.1016/j.antiviral.2018.06.014 URL
[31]	Jo S, Kim S, Shin DH, et al. Inhibition of African swine fever virus protease by myricetin and myricitrin[J]. J Enzyme Inhib Med Chem, 2020,35(1):1045-1049. doi: 10.1080/14756366.2020.1754813 URL
[32]	Fasina FO, Olaokun OO, Oladipo OO, et al. Phytochemical analysis and in vitro anti-African swine fever virus activity of extracts and fractions of Ancistrocladus uncinatus, Hutch and Dalziel(Ancistrocladaceae)[J]. BMC Vet Res, 2013,9:120. doi: 10.1186/1746-6148-9-120 URL
[33]	Galindo I, Hernáez B, Berná J, et al. Comparative inhibitory activity of the stilbenes resveratrol and oxyresveratrol on African swine fever virus replication[J]. Antiviral Res, 2011,91(1):57-63. doi: 10.1016/j.antiviral.2011.04.013 URL
[34]	Fabregas J, García D, Fernandez-Alonso M, et al. In vitro inhibition of the replication of haemorrhagic septicaemia virus(VHSV)and African swine fever virus(ASFV)by extracts from marine microalgae[J]. Antiviral Res, 1999,44(1):67-73. doi: 10.1016/S0166-3542(99)00049-2 URL
[35]	Madureira AM, Ascenso JR, Valdeira L, et al. Evaluation of the antiviral and antimicrobial activities of triterpenes isolated from Euphorbia segetalis[J]. Nat Prod Res, 2003,17(5):375-380. pmid: 14526920
[36]	Keita D, Heath L, Albina E. Control of African swine fever virus replication by small interfering RNA targeting the A151R and VP72 genes[J]. Antivir Ther, 2010,15(5):727-736. doi: 10.3851/IMP1593 URL
[37]	Frouco G, Freitas FB, Coelho J, et al. DNA-binding properties of African swine fever virus pA104R, a histone-like protein involved in viral replication and transcription[J]. J Virol, 2017,91(12):e02498-16.
[38]	Hübner A, Petersen B, Keil GM, et al. Efficient inhibition of African swine fever virus replication by CRISPR/Cas9 targeting of the viral p30 gene(CP204L)[J]. Sci Rep, 2018,8(1):1449. doi: 10.1038/s41598-018-19626-1 URL
[39]	Frouco G, Freitas FB, Martins C, et al. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14[J]. Virus Res, 2017,242:24-29. doi: 10.1016/j.virusres.2017.09.009 URL
[40]	Ziem B, Rahn J, Donskyi I, et al. Polyvalent 2D entry inhibitors for pseudorabies and African swine fever virus[J]. Macromol Biosci, 2017. DOI: 10.1002/mabi.201600499.
[41]	Niederwerder MC, Dee S, Diel DG, et al. Mitigating the risk of African swine fever virus in feed with anti-viral chemical additives[J]. Transbound Emerg Dis, 2020. DOI: 10.1111/tbed.13699.
[42]	王卓亚, 李阳阳, 徐锡明, 等. 以非洲猪瘟病毒DNA聚合酶X为靶点的海洋药物计算机虚拟筛选[J]. 中国海洋药物, 2018,37(6):1-7.
	Wang ZY, Li YY, Xu XM, et al. Virtual drug screening of marine natural products targeting African swine fever virus DNA polymerase X[J]. Chinese J Marine Drugs, 2018,37(6):1-7.
[43]	Kinyanyi D, Amwayi P, Wamalwa M, et al. Comparative in silico study of congocidine congeners as potential inhibitors of African swine fever virus[J]. PLoS One, 2019,14(8):e0221175. doi: 10.1371/journal.pone.0221175 URL