Biotechnology Bulletin ›› 2019, Vol. 35 ›› Issue (6): 156-163.doi: 10.13560/j.cnki.biotech.bull.1985.2018-0968

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Roles of African Swine Fever Virus Structural Proteins in Viral Infection

OU Yun-wen1,2, LIU Li-jun3, DAI Jun-fei1, MA Bing1, ZHANG Yong-guang1, ZHANG Jie1   

  1. 1. State Key Laboratory of Veterinary Etiological Biology,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730046;
    2. Animal Disease Prevention and Control Center of Kaijiang County,Dazhou 636250;
    3. Animal Disease Prevention and Control Center of Dazhou,Dazhou 635099
  • Received:2018-11-11 Online:2019-06-26 Published:2019-07-08

Abstract: African swine fever(ASF)is an acute,lethal,and hemorrhagic porcine infectious disease caused by African swine fever virus(ASFV)which has been caused serious economic losses to the pig industry. ASFV is a double-stranded DNA virus. The viral genome contains between 150 and 167 open reading frames(ORFs),and encodes for more 200 proteins,around 50 of them are structural proteins. The structural proteins service as the major composition of viral particles,and play important roles in the assembly of virions,viral adsorption,entry and replication. This paper reviews the roles of ASFV structural proteins in viral infection,and provides guidelines for further studies in the structural proteins of ASFV.

Key words: African swine fever virus, structural proteins, pathogenic mechanism, infection