植物生物反应器制药的现状及展望

doi:10.13560/j.cnki.biotech.bull.1985.2015.10.005

摘要/Abstract

摘要： 随着生命科学的发展以及基因工程和分子生物学技术的迅速崛起, 人们能够利用不同生物体作为“工厂”生产出可供治疗人类疾病和具有保健功能的产品, 即生物制药。目前使用的生物反应器平台有细菌、酵母、昆虫细胞、哺乳动物细胞和植物表达系统, 其中以植物为平台的生物反应器以其技术操作简单和成本较低越来越受到人们的青睐。就植物生物反应器在生物制药领域的应用、存在的问题以及可以采取的改进措施进行了概述。同时针对目前生物制药发展的趋势, 对植物生物反应器的应用及推广进行了展望。

关键词: 生物制药, 药用蛋白, 植物生物反应器, 糖基化, 微小核糖核酸

Abstract: With recent advances on the development and techniques in the life sciences, particularly in genetic engineering and molecular biology, a diverse range of organisms as “factories” can be utilized to produce the products to cure human disease or for preventative measures, i.e., biopharmaceuticals. Currently, bacterial, yeast, invertebrate and mammalian cells as well as plant expression system are already extensively utilized as bioreactors, whilst among them, plant bioreactors have shown the greatest potential, attracting world-wide attentions, due to their easy operation and cost efficiency. In this review, the applications of plant bioreactors, including existing problems and feasible modifying measures are summarized, followed by the prospects on the application and promotion of plant bioreactors based on the biopharmaceutical development trend.

Key words: biopharmaceutical, pharmaceutical proteins, plant bioreactor, protein glycosylation, microRNA

陈金梅,姜路壹,洪治. 植物生物反应器制药的现状及展望[J]. 生物技术通报, 2015, 31(10): 1-7.

Chen Jinmei, Jiang Luyi, Hong Zhi. Present Situation and Prospects on Application of Plant Bioreactor in Pharmaceutical[J]. Biotechnology Bulletin, 2015, 31(10): 1-7.

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