线粒体丙酮酸转运载体（MPC）研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2018-0926

摘要/Abstract

摘要： 线粒体丙酮酸转运载体（Mitochondrial pyruvate carrier,MPC）位于线粒体内膜,可将丙酮酸由细胞质运输至线粒体基质参与三羧酸循环、糖异生以及脂质、氨基酸等代谢过程,进而为机体提供能量,因此,MPC可通过调节丙酮酸进入线粒体基质的通量从而调控能量代谢。总结了MPC的生物学特性及其与代谢类疾病关系的研究进展。现有研究表明,MPC活性受到抑制后可导致肝脏糖异生速率降低,进而影响葡萄糖稳态,降低Ⅱ型糖尿病的发生;同时也可通过影响葡萄糖刺激的胰岛素分泌,阻止胰岛素信号的传导,导致机体对于外界葡萄糖的摄取不敏感,因此MPC对于机体葡萄糖稳态维持的十分重要。但是在大多数癌组织中MPC的活性受到抑制,应通过特异性地激活癌细胞中MPC功能,增强其有氧代谢,抑制癌细胞利用乳酸供能,进而抑制癌细胞的增殖。由此可见,MPC是研究基础能量代谢调控的切入点以及潜在的治疗靶位点,同时也为肥胖、糖尿病、癌症等代谢类疾病的研究提供了新的治疗思路。

关键词: 丙酮酸, 线粒体丙酮酸转运载体, 能量代谢

Abstract: The mitochondrial pyruvate carrier（MPC）in mitochondrial inner membrane transports the pyruvate from the cytoplasm to the mitochondrial matrix. The pyruvate involves in the tricarboxylic acid cycle,gluconeogenesis,and the metabolic processes such as lipids and amino acids,which provides energy to the body. Therefore,MPC regulates energy metabolism by controlling the flux of pyruvate into the mitochondrial matrix. This paper summarized the biological characteristics of MPC and its relationship with metabolic diseases. It has been found that inhibition of MPC activity may lead to a decrease in hepatic gluconeogenesis,which in turn affects glucose homeostasis and reduces the incidence of typeⅡdiabetes. It also prevents the transmission of insulin signaling by affecting glucose-stimulated insulin secretion,resulting in that body is not sensitive to external glucose uptake;thus the MPC complex is essential to the glucose homeostasis. However,the activity of MPC is inhibited in most cancer tissues,specifically activating the MPC function should be conducted to enhance its aerobic metabolism,to inhibit that the cancer cells use lactic acid to supply energy and subsequently to hinder the proliferation of cancer cells. MPC is considered to be an initial point for studying energy metabolism regulation and potential therapeutic target sites,and also provides new therapeutic ideas for studying metabolic diseases such as obesity,diabetes and cancers.

Key words: pyruvate, the mitochondrialpyruvate carrier, energy metabolism

解文雅, 邹世颖, 高如心, 贺晓云. 线粒体丙酮酸转运载体（MPC）研究进展[J]. 生物技术通报, 2019, 35(7): 196-201.

XIE Wen-ya, ZOU Shi-ying, Gao Ru-xin, HE Xiao-yun. Research Progress on the Mitochondrial Pyruvate Carrier（MPC）[J]. Biotechnology Bulletin, 2019, 35(7): 196-201.

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