植物SUMO E3连接酶研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2025-0637

摘要/Abstract

摘要：

SUMO化修饰作为真核生物中一种重要的可逆蛋白翻译后修饰形式，通过调控蛋白质的稳定性、亚细胞定位和活性参与植物的多种生命活动过程。SUMO化修饰过程由一系列酶促级联反应介导，其中SUMO E3连接酶在靶蛋白选择中具有决定性作用。近年研究发现，SUMO E3连接酶通过介导对多类靶蛋白的SUMO化修饰，在植物的生长发育与逆境适应中发挥关键调控作用。本文系统综述了植物中SUMO E3连接酶的结构特征、功能分化及其在多种生理过程中的调控网络，重点梳理其在非生物胁迫响应、生长发育以及免疫应答调控中的分子机制及信号整合途径，旨在为深入解析植物SUMO化修饰的调控网络与生物学功能提供理论参考，并为作物抗性改良与高产育种提供潜在靶点。

关键词: SUMO化修饰, SUMO E3连接酶, 植物胁迫响应, 生长发育

Abstract:

As a crucial reversible post-translational modification form of proteins in eukaryotes, sumoylation participates in various life processes in plants by regulating the stability, subcellular localization, and activity of proteins. Sumoylation modification is mediated by a serial of enzymatic cascade reactions, among which the SUMO E3 ligases plays a decisive role in the selection of target proteins. Recent studies have revealed that SUMO E3 ligases play pivotal regulatory roles in growth, development, and stress adaptation of plants by mediating the sumoylation modification of multiple types of target proteins. This review systematically summarizes the structural characteristics, functional differentiation of SUMO E3 ligases in plants and their regulatory networks in various physiological processes. It focuses on their roles in the molecular mechanisms and signaling integration pathways involved in abiotic stress responses, developmental regulation, and immune response, aiming to provide a theoretical basis for elucidating the regulatory networks and biological functions of plant sumoylation modification, and offer potential targets for crop stress resistance improvement and high-yield breeding.

Key words: sumoylation, SUMO E3 ligase, plant response to stress, growth and development

方玉洁, 刘宽, 崔寒冰, 王幼平. 植物SUMO E3连接酶研究进展[J]. 生物技术通报, 2025, 41(12): 1-15.

FANG Yu-jie, LIU Kuan, CUI Han-bing, WANG You-ping. Recent Advances in Plant SUMO E3 Ligases[J]. Biotechnology Bulletin, 2025, 41(12): 1-15.

图/表 3

图1 拟南芥与水稻中SUMO E3连接酶的保守结构域A. SUMO E3连接酶的保守结构域示意图；B. SUMO E3连接酶的三级结构预测

Fig. 1 Conserved domains of SUMO E3 ligases in Arabidopsis and riceA. Diagram of conserved domains of SUMO E3 ligases. B. Prediction of the tertiary structure of SUMO E3 ligases

图2 SUMO E3连接酶介导的SUMO化修饰在植物非生物胁迫响应中的调控网络：SIZ1介导的SUMO化；：MMS21介导的SUMO化；→：正调节；：负调节

Fig. 2 The regulatory network of SUMO E3 ligase-mediated sumoylation in plant abiotic stress responses: SIZ1-mediated sumoylation; : MMS21-mediated sumoylation; →: positive regulation; : negative regulation

图3 SUMO E3连接酶介导的SUMO化修饰在植物生长发育中的调控网络：SIZ1介导的SUMO化；：MMS21介导的SUMO化；→：正调节；：负调节

Fig. 3 Regulatory network of SUMO E3 ligase-mediated sumoylation in plant growth and development: SIZ1-mediated sumoylation; : MMS21-mediated sumoylation; →: positive regulation; : negative regulation

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