病原菌毒力因子诱导宿主细胞凋亡机理的研究进展

摘要/Abstract

摘要： 细胞凋亡可能在病理条件下发生, 其中细菌感染在引起细胞凋亡方面扮演着非常重要的角色。致病菌可通过激活某些促凋亡因子或者抑制某些抗凋亡因子的活性, 改变宿主细胞信号通路进而诱发细胞凋亡。近些年, 研究者对细菌诱导宿主细胞凋亡的机理进行了大量研究发现, 细胞凋亡主要与致病菌的毒力因子有关。结合当前的研究成果, 对病原菌毒力因子诱导机体细胞凋亡的作用机理进行归纳总结, 并对病原菌毒力因子诱导宿主细胞凋亡机理在癌症及某些抗药性细菌性疾病方面治疗的应用前景进行探讨与展望。

关键词: 细菌, 毒力因子, 宿主细胞, 凋亡

Abstract: Apoptosis may occurs under pathological conditions and is sometimes accompanied by necrosis. In particular, bacterial infections play an important role in triggering apoptosis. Pathogenic bacteria can trigger apoptosis by activating some factor or suppress inhibitors of apoptosis, then change the host cell signaling pathways and induce cell apoptosis. In recent years, researchers have found that cell apoptosis is mainly related to pathogenic bacteria of virulence factor. Here, we reviewed the mechanism of host cell apoptosis induced by pathogen virulence factors, which aims at revealing the integrated effects of bacterial virulence factor triggering host apoptosis, and the same kind of bacteria can trigger to cell apoptosis through different mechanisms. Finally, with the help of current research progress and our own studies, we discussed and prospected pathogen virulence factor induced host cell apoptosis mechanism and application prospect, and discovered the pathogen virulence factor is of great potential in cancer and some bacterial resistant diseases.

Key words: Bacteria, Virulence, Factor, Host cell, Apoptosis

胡庆亮, 李凌娟, 王潇. 病原菌毒力因子诱导宿主细胞凋亡机理的研究进展[J]. 生物技术通报, 2013, 0(6): 32-38.

Hu Qingliang, Li Lingjuan, Wang Xiao. Progress in the Mechanism of Host Cell Apoptosis Induced by Pathogen Virulence Factors[J]. Biotechnology Bulletin, 2013, 0(6): 32-38.

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