生物技术通报 ›› 2019, Vol. 35 ›› Issue (2): 176-181.doi: 10.13560/j.cnki.biotech.bull.1985.2018-0707

• 综述与专论 • 上一篇    下一篇

LKB1-AMPKα-SIRT1信号通路在奶牛脂肪组织脂代谢中的调控作用

明鹏飞, 黄莹莹, 董妍丽, 聂星灿, 冯士彬, 王希春, 程建波, 李锦春, 吴金节, 李玉   

  1. 安徽农业大学动物科技学院,合肥 230036
  • 收稿日期:2018-08-06 出版日期:2019-02-26 发布日期:2019-03-07
  • 作者简介:明鹏飞,男,硕士研究生,研究方向:畜禽营养代谢病;E-mail:1396648612@qq.com
  • 基金资助:
    国家自然科学基金项目(31502136),安徽省自然科学基金项目(1608085QC56),安徽省牛羊产业技术体系(AHCYJSTX-07),2016年省级大学生创新创业训练计划项目(201610364009)

Regulation of LKB1-AMPKα-SIRT1 Signal Pathway in Lipid Metabolism in the Adipose Tissue of Dairy Cows

MING Peng-fei, HUANG Ying-ying, DONG Yan-li, NIE Xing-can, FENG Shi-bin, WANG Xi-chun, CHENG Jian-bo, LI Jin-chun, WU Jin-jie, LI Yu   

  1. College of Animal Science and Technology,Anhui Agricultural University,Hefei 230036
  • Received:2018-08-06 Published:2019-02-26 Online:2019-03-07

摘要: 奶牛脂肪细胞体积和数目的不断增加会导致脂肪组织脂代谢的紊乱,引起一系列相关慢性疾病如Ⅱ型糖尿病、酮病、脂肪肝、高脂血症等的发生,LKB1-AMPKα-SIRT1信号通路在奶牛脂肪组织脂代谢中起着重要的调控作用。单磷酸腺苷活化蛋白激酶(AMPK)是比较保守的丝氨酸/苏氨酸激酶,在调节能量代谢中起着枢纽作用。肝激酶B1(LKB1)属于一种丝氨酸激酶,是AMPKα的上游激酶,可参与细胞内能量代谢等多种生物活动。沉默信息调节因子1(SIRT1)是一种NAD+依赖的组蛋白去乙酰化酶,可通过去乙酰化LKB1增加AMPKα的活性。就LKB1-AMPKα-SIRT1信号转导通路在奶牛脂肪组织脂代谢紊乱中的调控机制作一综述,旨在为下一步研究奶牛脂代谢相关信号通路调控机理提供依据。

关键词: LKB1, AMPKα, SIRT1, 奶牛, 脂肪组织, 脂质代谢

Abstract: The increasing volume and number of adipocyte leads to disorder of lipid metabolism in adipose tissue,which causes different chronic diseases such as type II diabetes,ketosis,fatty liver,and hyperlipidemia. The LKB1-AMPKα-SIRT1 signal pathway plays important regulating role in the lipid metabolism of dairy cows adipose tissue. AMPK as conservative serine/threonine kinase plays a pivotal role in the regulation of energy metabolism. LKB1(liver kinase B1)is a serine/threonine kinase,an upstream kinase of AMPKα,participates in various biological activities such as intracellular energy metabolism. Silencing information regulator factor 1(SIRT1),a kind of NAD+-dependent histone deacetylase,can increase AMPKα activity by deactivating LKB1. This article reviews the regulation mechanisms of LKB1-AMPKα-SIRT1 signal transduction pathways in lipid metabolism of adipose tissue in dairy cows,aiming at providing a basis for further studying the regulating mechanisms of related signal pathways in the lipid metabolism of dairy cows.

Key words: LKB1, AMPKα, SIRT1, dairy cows, adipose tissue, lipid metabolism