畜禽PPARα基因研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2018-0504

摘要/Abstract

摘要： 过氧化物酶体增殖物激活受体（Peroxisome proliferator-activated receptors,PPARs）是核激素受体家族中的配体激活受体,控制许多细胞内的代谢过程,PPARα作为过氧化物酶体增殖物激活受体家族重要成员之一,是调控机体脂质代谢的重要枢纽,在调控畜禽机体肝脏脂质代谢方面有重要作用。PPARα基因由四个结构域组成,多在机体肝脏和脂肪组织中表达,可作为细胞核受体被外源和内源的特异性配体结合并激活,进而结合靶基因发挥对肝脏脂质代谢的调控作用。就PPARα基因的结构特点及表达模式、PPARα基因对肝脏脂代谢的调控机制,以及现阶段PPARα在畜禽方面的研究进展进行阐述,旨在引起人们对PPARα基因调控脂质代谢的关注,并为畜禽肝脏脂质代谢过程的机理研究和相关疾病的治疗提供一些理论支持。

关键词: PPARα, 基因, 核受体, 肝脏, 脂质代谢

Abstract: The peroxisome proliferator activator receptor（PPARs）is the ligand activator receptor in the nuclear hormone receptor family,and controls the metabolic process in many cells. As an important member of the peroxisome proliferator activated receptor family,PPARα is a key hub for regulating body lipid metabolism,and plays a critical role in regulating lipid metabolism in the liver of livestock and poultry. PPARα genes are composed of 4 structural domains and are mostly expressed in the liver and adipose tissue of body. PPARα as a nuclear receptor is activated by binding exogenous and endogenous specific ligands,then binds to the target gene to exert a regulatory role in the liver lipid metabolism of body. In this paper we respectively review the structure characteristics of PPARα and its expression pattern,the regulation mechanism of PPARα gene on lipid metabolism in liver,and the research progress of PPARα in livestock and poultry at present stage,aiming at raising awareness of PPARα regulation in lipid metabolism and providing theoretical supports for studying mechanism of lipid metabolism in the livers of livestock and poultry and the treatment of related diseases.

Key words: PPARα, gene;, nuclear receptor, liver, lipid metabolism

王朝阳, 蓝立明, 白丁平, 张福君, 李昂. 畜禽PPARα基因研究进展[J]. 生物技术通报, 2018, 34(12): 32-40.

WANG Zhao-yang, LAN Li-ming, BAI Ding-ping, ZHANG Fu-jun, LI Ang. Research Advance on PPARα Gene in Livestock and Poultry[J]. Biotechnology Bulletin, 2018, 34(12): 32-40.

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