食源性致病微生物危害风险及其防控用抗菌生物活性肽研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2018-1010

摘要/Abstract

摘要： 食源致病微生物是污染食品、食用农产品的主要生物危害物,严重威胁人类及动物健康;同时也给食品、食用农产品产业造成巨大经济损失,是制约产业健康可持续发展的关键危害因素。传统依赖抗生素对致病微生物的防控效果显著,但由于抗生素长期的不合理使用甚至是滥用所诱发产生的致病微生物耐药性,以及对人类和动物体内脏器、肠道组织、神经和代谢系统正常功能构成的潜在危害性等问题也同样突出。抗菌生物活性肽作为具有抗菌功能的生物多肽类蛋白质,被认为是对人类、动物以及生态环境友好的抗菌物质,有望替代抗生素用于致病微生物的防控,现已成为探索新型安全抗菌类药物研发的热点。全面梳理了食源致病微生物种类、污染特点及其主要危害风险;系统概述了抗菌生物活性肽主要类型、来源及其创制技术;着重介绍了当前抗菌生物活性肽在食源致病微生物防控上的研究状况,并深入探讨了其应用前景、存在问题及拟解决对策,旨在为食品、食用农产品中食源性致病微生物筛查以及靶向防控技术提供最新的有参考价值的文献资料和创新思路。

关键词: 食品质量安全, 食源致病微生物, 抗菌生物活性肽, 生物防控

Abstract: Food-borne pathogenic microorganisms are the main biological hazards that contaminate food and edible-agricultural products and seriously threaten the health of humans and animals. At the same time,they also cause huge economic losses to food and edible-agricultural products industry,which is the key factor of restricting their development. Traditional dependence on antibiotics has a significant effect on pathogenic microorganism prevention and control. However,due to long-term unreasonable use or even abuse of antibiotics,the drug resistance of pathogenic microorganisms,as well as potential harmfulness to normal functions of internal organs,intestinal tissues,nervous and metabolic systems in humans and animals,are also prominent. Antimicrobial bioactive peptides,as biological peptides with antimicrobial functions,are considered as antimicrobial substances friendly to humans,animals and ecological environment,and they expected to replace antibiotics in pathogenic microorganism prevention and control. Now,antimicrobial bioactive peptide has become a hot spot to explore new and safe antibacterial drugs. In this paper,we comprehensively sort out their types,pollution characteristics and main hazard risks of food-borne pathogenic microorganisms,and systematically summarize their main types and source of antimicrobial bioactive peptides and their creation techniques. Then we emphatically introduce the current research status of antimicrobial bioactive peptides for food-borne pathogenic microorganism prevention and control. Finally,we discuss their application prospect,existing issues and countermeasures. To sum up,this paper is to provide the latest references or innovative idea for screening as well as prevention and control of food-borne pathogenic microorganisms in food and edible agricultural products.

Key words: food quality and safety, food-borne pathogenic microorganism, antimicrobialbioactive peptides, biologicalprevention and control

徐重新, 张存政, 刘媛, 张霄, 仲建锋, 刘贤金. 食源性致病微生物危害风险及其防控用抗菌生物活性肽研究进展[J]. 生物技术通报, 2019, 35(7): 202-212.

XU Chong-xin, ZHANG Cun-zheng, LIU Yuan, ZHAG Xiao, ZHONG Jian-feng, LIU Xian-jin. Research Advance for the Hazard Risks and Antimicrobial Bioactive Peptides of Food-borne Pathogenic Microorganisms[J]. Biotechnology Bulletin, 2019, 35(7): 202-212.

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