细胞凋亡中MicroRNA的调控作用

摘要/Abstract

摘要： MicroRNA（miRNA）是一类内源性非编码小RNA, 广泛存在于多种生物体内, 通过调控靶基因的转录表达影响各种生命活动。细胞凋亡是细胞受到外部或者内部刺激后自发启动的基因控制的程序性死亡。最近几年, 越来越多的研究表明miRNAs通过靶向调控凋亡基因或者凋亡信号传导从而直接或间接地参与到细胞凋亡的产生和发展。综述miRNA和细胞凋亡的关系, 揭示miRNA调控细胞凋亡的分子机制。

关键词: MicroRNA, 细胞凋亡, 基因, 信号通路

Abstract: MicroRNA（miRNA）, a class of non-coding small RNA molecules, widely exists in the most of the animals and plants. Major function of MicroRNA is expression regulation of target gene. This regulation is primarily carried out by repression of translation in mammals. Apoptosis is programmed cell death regulated by various genes and the role of miRNAs in apoptosis is not fully understood, however, evidence is mounting that miRNAs are important in this process. In this paper, the relationship between MicroRNA and cell apoptosis, and concludes the possible regulation mechanism were reviewed.

Key words: MicroRNA, Apoptosis, Gene, Signal pathway

齐仁立, 黄金秀, 杨飞云, 刘作华. 细胞凋亡中MicroRNA的调控作用[J]. 生物技术通报, 2014, 0(7): 20-25.

Qi Renli, Huang Jinxiu, Yang Feiyun, Liu Zuohua. Role of MicroRNAs in Genes Regulatory Apoptosis[J]. Biotechnology Bulletin, 2014, 0(7): 20-25.

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