MicroRNA与NF-κB调控的细胞凋亡

doi:10.13560/j.cnki.biotech.bull.1985.2015.05.005

摘要/Abstract

摘要： NF-κB是一种非常重要的核转录调控因子，激活后的NF-κB通过调节靶基因的转录表达参与细胞的各项生命活动，特别是炎症、免疫和凋亡。NF-κB在不同类型的细胞凋亡中可能发挥不同的调控作用。而microRNA这类非编码的RNA对于NF-κB的表达和功能又能够产生系统性或者特异性的调节。综述分析NF-κB对细胞凋亡的调控作用，并探讨microRNA在此过程中的作用。

关键词: NF-κB, microRNA, 细胞凋亡

Abstract: As a key regulatory factor in cell, activated NF-κB induces the transcription of target genes involved in many cell activities, especially the inflammation, immunity and apoptosis. Previous studies proved that NF-κB plays various roles in different type of apoptosis. Moreover, expression and function of NF-κB could be systematically or specifically regulated by microRNA of non-encoding RNAS. The mediating effects of NF-κB on apoptosis were summarized, and the role of microRNA in the mediating process were further discussed .

Key words: NF-κB, microRNA, Apoptosis

齐仁立, 黄金秀, 龙定彪, 黄萍. MicroRNA与NF-κB调控的细胞凋亡[J]. 生物技术通报, 2015, 31(5): 27-31.

Qi Renli, Huang Jinxiu, Long Dingbiao, Huang Ping. The Role of MicroRNA in the Cell Apoptosis Mediated by NF-κB[J]. Biotechnology Bulletin, 2015, 31(5): 27-31.

参考文献

[1] Sen R, Baltimore D. lnducibility of κ immunoglobulin enhancer-binding protein NF-κB by a post translational mechanism[J]. Cell, 1986, 46：705-716.
[2] Gilmore TD. Introduction to NF-κB：players, pathways, perspectives[J]. Oncogene, 2006, 25：6680-6684.
[3] Beg AA, Baltimore D. An essential role for NF-B in preventing TNFα induced cell death[J]. Science, 1996, 274：782-784.
[4] O’Neilla LAJ, Kaltschmidtb C. NF-kB：a crucial transcription fac-tor for glial and neuronal cell function[J]. Trends in Neuroscien-ces, 1997, 20（6）：252-258.
[5] Bonizzi G, Karin M. The two NF-KappaB activation pathways and their role in innate and adaptive immunity[J]. Trends Immunol, 2004, 25：280-288.
[6] Karin M. Nuclear factor-kappa B in cancer development and progression[J]. Nature, 2006, 441（7092）：431-436.
[7] Alberts B, Johnson A, Lewis J, et al. "Chapter 18 Apoptosis：programmed cell death eliminates unwanted cells"［C] //Molecular Biology of the Cell（textbook）. 5th ed. New York：Garland Science, 2008：1115.
[8] Mitchell TC, Hildeman D, Kedl RM, et al. Immunological adjuvants promote activated T cell survival via induction of Bcl-3[J]. Nat Immunol, 2001, 2：397-402.
[9] Van Antwerp DJ, Martin SJ, Kafri T, et al. Suppression of TNFα induced apoptosis by NF-κB[J]. Science, 1996, 274：787-789.
[10] Wang CY, Mayo W, Baldwin AS. TNFα and cancer therapyinduced apoptosis potentiation by inhibition of NF-κB[J]. Science, 1996, 274：784-787.
[11] Alcamo E, Mizgerd JP, Horwitz BH, et al. Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kB in leukocyte recruitment[J]. J Immunol, 2001, 167：1592-1600.
[12] Baichwal VR, Baeuerle PA. Apoptosis：Activate NF-kB or die?[J]. Curr Biol, 1997, 7（2）：94-96.
[13] Zong WX, Edelstein LC, Chen C, et al. The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-κB that blocks TNFα induced apoptosis[J]. Genes Dev, 1999, 13：382-387.
[14] Khoshnan AC, Tindell I, Laux D, et al. The NF-κB cascade is important in Bcl-xL expression and for the antiapoptotic effects of the CD28 receptor in primary human CD4 lymphocytes[J]. J Immunol, 2000, 165：1743-1754.
[15] Grumont RJ, Rourke IJ, Gerondakis S. Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis[J]. Genes Dev, 1999, 13：400-411.
[17] Wu MX, Ao Z, Prasad KVS, et al. IEX-1L, an apoptosis inhibitor involved in NF-κB-mediated cell survival[J]. Science, 1998, 281：998-1001.
[17] Wang CY, Mayo W, Korneluk RG, et al. NF-κB anti-apoptosis：induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation[J]. Science, 1998, 281：1680-1683.
[18] Beg A, Sha W, Bronson R, et al. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB[J]. Nature, 1995, 376：167-170.
[19] Doi TS, Marino MW, Takahashi T, et al. Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality[J]. Proc Natl Acad Sci USA, 1999, 96：2994-2999.
[20] Stefan G, Bauer MKA, Patrick A, et al. Bcl-2 Down-regulates the activity of transcription factor NF-κB induced upon apoptosis[J]. The Journal of Cell Biology, 1996, 134（1）：13-23.
[21] Ryan KM, Ernst MK, Rice NR, et al. Role of NF-k B in p53-mediated programmed cell death[J]. Nature, 2000, 404（20）：892-897.
[22] Kaltschmidt B, Kaltschmidt C, Hofmann TG. The pro-or anti-apoptotic function of NF-kappa B is determined by the nature of the apoptotic stimulus[J]. Eur J Biochem, 2000, 267（12）：3828-3835.
[23] Liu FY, Bardhan KK, Yang DF, et al. NF-?B directly regulates Fas transcription to modulate Fas-mediated apoptosis and tumor suppression[J]. J Biol Chem, 2012, 287（30）：25530-25540.
[24] Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J]. Cell, 1993, 75（5）：843-854.
[25] Corce CM. Causes and consequences of microRNA dysregulation in cancer[J]. Nat Rev Genet, 2009, 10（10）：704-714.
[26] Zeng Y, Yi R, Cullen BR. MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms[J]. Proc Natl Acad Sci USA, 2003, 100：9779-9784.
[27] Friedman RC, Farh KK, Burge CB, et al. Most mammalian mRNAs are conserved targets of microRNAs[J]. Genome Res, 2009, 19（1）：92-105.
[28] Angelats MG, Cidlowski JA. Cell volume control and signal transduction in apoptosis[J]. Toxicologic Pathology, 2002, 30（5）：541-551.
[29] Zeng Y. Principles of micro-RNA production and maturation[J].Oncoqene, 2006, 25（46）：6156-6162.
[30] George AO, Anton L, Hwang YC, et al. A functional genomics screen for microRNA regulators of NF-kappaB signaling[J]. BMC Biology, 2013, 11：19.
[31] Ma XD, Buscaglia LEB, Barker JR, et al. MicroRNAs in NF-kB signaling[J]. Journal of Molecular Cell Biology, 2011, 3：159-166.
[32] Taganov KD, Boldin MP, Chang KJ, et al. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses[J]. Proc Natl Acad Sci USA, 2006, 103（33）：12481-12486.
[33] Paik JH, Jang JY, Jeon YK. MicroRNA-146a downregulates NF-κB activity via targeting TRAF6 and functions as a tumor suppressor having strong prognostic implications in NK/T cell lymphoma[J]. Clin Cancer Res, 2011, 17（14）：1-11.
[34] Kim SW, Ramasamy K, Bouamar H, et al. MicroRNAs miR-125a and miR-125b constitutively activate the NF-κB pathway by targeting the tumor necrosis factor alpha-induced protein 3（TNFAIP3, A20）[J]. Proc Natl Acad Sci USA, 2012, 109：7865-7870.
[35] Iliopoulos D, Jaeger SA, Hirsch HA, et al. STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer[J]. Mol Cell, 2010, 39：493-506.
[36] Lindesy EB, Yong L. Apoptosis and the targets genes of miR-21[J]. Chinese Journal of Cancer, 2011, 30（6）：371-380.
[37] Shin VY, Jin H, Ng EK. NF-κB targets miR-16and miR-21in gastric cancer：involvement of prostaglandin E receptors[J]. Carcinogenesis, 2011, 32：240-245.
[38] Mott JL, Kobayashi S, Bronk SF, Gores GJ. mir-29 regulates Mcl-1 protein expression and apoptosis[J]. Oncogene, 2007, 26：6133-6140.
[39] Xiong YJ, Fang JH, Yun JP, et al. Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma[J]. Hepatology, 2010, 51（3）：836-845.
[40] Satoshi S, Tetsuo T, Hayato H, et al. The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human[J]. Journal of Hepatology, 2010, 52（5）：698-704.