银纳米簇抗菌机理、活性及其应用的研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2020-0828

摘要/Abstract

摘要：

银纳米簇是一类粒径介于银原子和银纳米颗粒之间,由几个到几十个银原子组成,核心尺寸小于2 nm的银纳米材料。近年来银纳米簇以其固有的广谱抑菌性、不致耐药性、良好的生物相容性、低剂量有效性等优势在抗菌应用领域受到了较高的关注。综述了银纳米簇的抗菌机理及抗菌活性的影响因素,探讨其细胞毒性,并对目前已有的抗菌应用进行总结,展望了银纳米簇未来的应用方向及要突破的问题,着重突出DNA银纳米簇的广泛应用前景。

关键词: 银纳米簇, 抗菌机理, 抗菌活性, 细胞毒性, DNA

Abstract:

Silver nanoclusters are a class of silver nanomaterials whose particle sizes are between silver atoms and silver nanoparticles and consist of several to hundreds of silver atoms at a core size of less than 2 nm. In recent years,silver nanoclusters have attracted much attention in the field of antimicrobial application due to their inherent advantages such as broad-spectrum antibacterial activity,non-drug resistance,good biocompatibility and low dose effectiveness. In this paper,the antibacterial mechanisms and influencing factors of antibacterial activity of silver nanoclusters are reviewed,their cytotoxicity is discussed,and the existing antibacterial applications are summarized. The future application directions and breakthroughs of silver nanoclusters are prospected,and the wide application prospects of DNA silver nanoclusters are highlighted.

Key words: silver nanoclusters, antibacterial mechanism, antibacterial activity, cytotoxicity, DNA

龚晓惠, 杨敏, 李舒婷, 林晟豪, 许文涛. 银纳米簇抗菌机理、活性及其应用的研究进展[J]. 生物技术通报, 2021, 37(5): 212-220.

GONG Xiao-hui, YANG Min, LI Shu-ting, LIN Sheng-hao, XU Wen-tao. Progress on Antibacterial Mechanism,Activity and Application of Silver Nanoclusters[J]. Biotechnology Bulletin, 2021, 37(5): 212-220.

图/表 4

图1 AgNPs抑菌作用模式图[13]

Fig. 1 Routes of antibacterial action of AgNPs

图2 AgNCs对大肠杆菌的抑菌机制示意图[15]

Fig. 2 Schematic diagram of antibacterial mechanism of AgNCs against Escherichia coli

图3 AgNCs在微孔CS-PEG膜中原位浸渍示意图[52]

Fig. 3 Schematic diagram of in situ impregnation of AgNCs in microporous CS-PEG membranes

图4 Y-super-NC、X-super-NC和（Y-X）-super-NC合成过程及结构示意图[26]

Fig. 4 Schematic diagram of synthetic process and struc-ture of Y-super-NC, X-super-NC, and (Y-X)-super-NC

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