生物技术通报 ›› 2022, Vol. 38 ›› Issue (6): 43-52.doi: 10.13560/j.cnki.biotech.bull.1985.2021-1175

• 综述与专论 • 上一篇    下一篇

ABC转运蛋白结构及其在细菌致病性中的研究进展

陈福暖(), 黄瑜, 蔡佳, 王忠良, 简纪常, 王蓓()   

  1. 广东海洋大学水产学院 广东省水产经济动物病原生物学及流行病学重点实验室 广东省水产经济动物病害控制重点实验室,湛江 524088
  • 收稿日期:2021-09-14 出版日期:2022-06-26 发布日期:2022-07-11
  • 作者简介:陈福暖,男,硕士研究生,研究方向:水生动物医学;E-mail: Chenfunuan970716@126.com
  • 基金资助:
    国家自然科学基金项目(32002426);国家自然科学基金项目(U20A2065);国家自然科学基金项目(32073006);广东省科技厅国际科技合作领域项目(2019A050510044);广东省自然科学基金(2019A1515011875);广东海洋大学2019年“冲一流”省财政专项资金建设项目(校[2019]21号)

Structure of ABC Transporter and Research Progress of It in Bacterial Pathogenicity

CHEN Fu-nuan(), HUANG Yu, CAI Jia, WANG Zhong-liang, JIAN Ji-chang, WANG Bei()   

  1. Fisheries College,Guangdong Ocean University,Guangdong Provincial Key Laboratory of Pathogenic Biology and Epidemiology for Aquatic Economic Animals,Key Laboratory of Control for Diseases of Aquatic Economic Animals of Guangdong Higher Education Institute,Zhanjiang 524088
  • Received:2021-09-14 Published:2022-06-26 Online:2022-07-11

摘要:

ABC转运蛋白,即腺苷三磷酸结合盒转运蛋白(ATP-binding cassette transporter)是具有多种功能且分布极为广泛的膜蛋白质家族。它的主要功能是利用ATP水解产生的能量来实现对底物的跨膜转运,ABC超家族蛋白转运体普遍存在于细菌、真菌,线虫,果蝇、植物、哺乳动物等几乎所有生物体内。大多数ABC 转运蛋白最初是通过研究真核生物体耐药性(多效耐药和多药耐药)而被发现的。目前针对ABC转运蛋白在细菌致病性中所发挥作用也有广泛的研究。本文综述了ABC 转运蛋白的结构、转运机制和ABC转运蛋白在细菌致病性过程中的作用,讨论了深入研究ABC转运蛋白作用机制对细菌性疾病防治的意义及存在问题。ABC转运蛋白相关的细胞表面或分泌因子很可能是抗菌疗法或疫苗开发的作用靶点,为细菌性疾病的预防提供了新的思路。

关键词: ABC转运蛋白, 原核生物, 致病性, 毒力, 耐药性

Abstract:

Adenosine triphosphate binding cassette transporter(ATP-binding cassette transporter,ABC transporter)is known as the most numerous protein family with multiple roles. Functionally,ABC transporter mediate the cross-membrance transmission of multiple substrates by using the energy generated by ATP hydrolysis. ABC transporters exist in most organisms including bacteria,fungi,nematodes,fruit flies,plants,and mammals. Most of ABC transporters were originally discovered by studying the drug resistance(multiple drug resistance and multidrug resistance)of eukaryotes. Recently,there are broad researches on the roles of ABC transporters in bacterial pathogenicity. This paper summarized the structure and mechanism of ABC transporter and the role of it in bacterial pathogenicity,discussed the significance and issues in further studying the mechanism of ABC transporter and control of bacterial diseases. The cell surface or secretory factors associated with ABC transporters is potential targets of antimicrobial therapy or vaccine development,which provides a new idea for the prevention of bacterial diseases.

Key words: ATP-binding cassette, prokaryotes, pathogenicity, virulence, drug resistance