Research Progress on Circular RNA

doi:10.13560/j.cnki.biotech.bull.1985.2018-0127

Abstract

Abstract: Circular RNA（circRNA）appears in the splicing process of transcription,and single-stranded RNA molecules form a ring via covalent bonding. The development of high-throughput sequencing technology allows a comprehensive study of noncoding linear RNA（NCL）,this makes the NCL re-entering into the researcher's vision,especially the circRNA. circRNA has been proved to have features of rich,highly expressed,and evolutionary conservative. Some circRNAs have been demonstrated to have the functions that can affect the regulation of microRNA to genes,can be used as the miRNA sponges,can regulate the transcription of parent gene,and also have translation function and some other functions. It plays an important role in some diseases,and has a regulating effect on Alzheimer's disease,diabetes,ischemic heart disease and some other cancers. It can not only regulate the progression of diseases but also can be used as a biological marker for disease detection. Therefore in this paper,we give the overview about biogenesis,function,detection methods of circRNAs,novel circRNA identification and their associations with diseases,and we prospect its further study.

Key words: circular RNA, noncoding, regulation, detection, identification, association with disease

LI Hong-yu, XU Wen-tao. Research Progress on Circular RNA[J]. Biotechnology Bulletin, 2018, 34(12): 21-31.

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