[1] Berger M, Kaup M, Blanchard V.Protein glycosylation and its impact on biotechnology[J]. Advances in Biochemical Engineering/Biotechnology, 2012, 127:165-185. [2] Boyd PN, Lines AC, Patel AK.The effect of the removal of sialic acid, galactose and total carbohydrate on the functional activity of campath-1h[J]. Mol Immunol, 1995, 32(17-18):1311-1318. [3] Group TCBW.A-mab:A case study in bioprocess development[EB/OL]. CASSS, 2009:37-38. [4] Shields RL, Lai J, Keck R, et al.Lack of fucose on human igg1 n-linked oligosaccharide improves binding to human fcgamma riii and antibody-dependent cellular toxicity[J]. J Biol Chem, 2002, 277(30):26733-26740. [5] Alessandri L, Ouellette D, Acquah A, et al.Increased serum clearance of oligomannose species present on a human IgG1 molecule[J]. MAbs, 2012, 4(4):509-520. [6] Goetze AM, Liu YD, Zhang Z, et al.High-mannose glycans on the fc region of therapeutic igg antibodies increase serum clearance in humans[J]. Glycobiology, 2011, 21(7):949-959. [7] Liu H, Nowak C, Shao M, et al.Impact of cell culture on recombinant monoclonal antibody product heterogeneity[J]. Biotechnology Progress, 2016, 32(5):1103-1112. [8] St Amand MM, Hayes J, Radhakrishnan D, et al.Identifying a robust design space for glycosylation during monoclonal antibody production[J]. Biotechnology Progress, 2016, 32(5):1149-1162. [9] McCracken NA, Kowle R, Ouyang A. Control of galactosylated glycoforms distribution in cell culture system[J]. Biotechnology Progress, 2014, 30(3):547-553. [10] Cabrera G, Salazar V, Montesino R, et al.Structural characterization and biological implications of sulfated n-glycans in a serine protease from the neotropical moth hylesia metabus(cramer[1775])(lepidoptera:Saturniidae)[J]. Glycobiology, 2016, 26(3):230-250. [11] Grainger RK, James DC.Cho cell line specific prediction and control of recombinant monoclonal antibody n-glycosylation[J]. Biotechnol Bioeng, 2013, 110(11):2970-2983. [12] St Amand MM, Radhakrishnan D, Robinson AS, et al.Identification of manipulated variables for a glycosylation control strategy[J]. Biotechnol Bioeng, 2014, 111(10):1957-1970. [13] Gramer MJ, Eckblad JJ, Donahue R, et al.Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose[J]. Biotechnol Bioeng, 2011, 108(7):1591-1602. [14] Pacis E, Yu M, Autsen J, et al.Effects of cell culture conditions on antibody n-linked glycosylation-what affects high mannose 5 glycoform[J]. Biotechnol Bioeng, 2011, 108(10):2348-2358. [15] Kang S, Zhang Z, Richardson J, et al.Metabolic markers associated with high mannose glycan levels of therapeutic recombinant monoclonal antibodies[J]. J Biotechnol, 2015, 203:22-31. [16] Gascon P.The evolving role of biosimilars in haematology-oncology:A practical perspective[J]. Ther Adv Hematol, 2015, 6(6):267-281. [17] Hossler P, Racicot C, Chumsae C, et al.Cell culture media supplementation of infrequently used sugars for the targeted shifting of protein glycosylation profiles[J]. Biotechnology Progress, 2017, 33(2):511-522. [18] Fan Y, Jimenez Del Val I, Muller C, et al. Amino acid and glucose metabolism in fed-batch cho cell culture affects antibody production and glycosylation[J]. Biotechnol Bioeng, 2015, 112(3):521-535. [19] Rivinoja A, Hassinen A, Kokkonen N, et al.Elevated golgi ph impairs terminal n-glycosylation by inducing mislocalization of golgi glycosyltransferases[J]. J Cell Physiol, 2009, 220(1):144-154. [20] Gawlitzek M, Ryll T, Lofgren J, et al.Ammonium alters n-glycan structures of recombinant tnfr-igg:Degradative versus biosynthetic mechanisms[J]. Biotechnol Bioeng, 2000, 68(6):637-646. [21] Davami F, Eghbalpour F, Nematollahi L, et al.Effects of peptone supplementation in different culture media on growth, metabolic pathway and productivity of cho dg44 cells;a new insight into amino acid profiles[J]. Iranian Biomedical Journal, 2015, 19(4):194-205. [22] Spearman M, Lodewyks C, Richmond M, et al.The bioactivity and fractionation of peptide hydrolysates in cultures of cho cells[J]. Biotechnology Progress, 2014, 30(3):584-593. [23] Ho SC, Nian R, Woen S, et al.Impact of hydrolysates on monoclonal antibody productivity, purification and quality in chinese hamster ovary cells[J]. J Biosci Bioeng, 2016, 122(4):499-506. |