Application of RNA Interference Technology in Antiviral and Antiparasitic Research of Aquatic Animals

doi:10.13560/j.cnki.biotech.bull.1985.2019-0908

Abstract

Abstract: RNA interference（RNAi）is a post-transcriptional gene silencing mechanism mediated by double-stranded RNA which inhibits the expression of target genes,and is widely found in eukaryotes. With the development of aquaculture in recent years,diseases of aquatic animals often break out,bringing huge economic losses to farmers. Currently,the mechanism of aquatic animal diseases caused by viruses and parasites still needs to be further studied. The emergence of RNA interference technology provides a powerful tool for studying the pathogenic mechanism of aquatic animal diseases. In this paper,the discovery,mechanism and application of RNA interference in the antiviral and antiparasitic research of aquatic animals are reviewed,and the future research and application of RNAi technology in the prevention and treatment of aquatic animal disease are prospected,providing reference for the control of diseases in aquatic animals.

Key words: RNA interference, aquatic animals, antiviral, antiparasitic, application

SONG Hua-li, SUN Xiao-ying, KONG Xiang-hui, LI Li, PEI Chao. Application of RNA Interference Technology in Antiviral and Antiparasitic Research of Aquatic Animals[J]. Biotechnology Bulletin, 2020, 36(2): 193-205.

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