Research Progress on DNA Guanine Quadruplex

doi:10.13560/j.cnki.biotech.bull.1985.2020-0205

Abstract

Abstract: G-quadruplex（G4）refers to a four-stranded secondary structure formed by guanine-rich nucleic acid sequences through Hoogsteen hydrogen bonding in the DNA or RNA strand. Studies of G4 in humans and animals demonstrate that G4 is involved in a wide range of basic biological functions such as DNA replication,transcription,translation,and maintenance of telomeric structure. By contrast,researches on the biological functions of G4 in plants have lagged way behind. This paper reviews the research progress on the methodologies,biological functions and possible mechanisms of DNA G4s in humans and animals,summarizes the research status and possible biological functions of G4 in plants,and finally prospects the application of G4 in diagnosis and treatment of human diseases as well as molecular crop breeding.

Key words: G4, DNA, research method, biological functions

FENG Yi-long, ZHANG Wen-li. Research Progress on DNA Guanine Quadruplex[J]. Biotechnology Bulletin, 2020, 36(7): 23-31.

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