Structure and Catalytic Mechanism of Bacterial Urease Protein

doi:10.13560/j.cnki.biotech.bull.1985.2020-0459

Abstract

Abstract:

Bacterial urease catalyzes the efficient decomposition of urea to produce ammonia;however,high activity of urease has negative influence on human healthy,agriculture,environment,and so on. It is of great scientific significance to research characteristics of bacterial urease and study how to inhibit urease activity. With the rapid development of molecular and structural biology,more and more structures of urease have been analyzed,and the regulation mechanism of urease activity has been improved constantly,which mark a new stage of urease protein research. This review summarizes the crystal structure and active center characteristics of bacterial urease,catalytic mechanism,mechanism of urease inhibitors,in order to provide some references to urease regulation research.

Key words: bacterial urease, structural protein, crystal structure, inhibition mechanism

HE Yue, ZHAO Sheng-guo, ZHANG Xiao-yin, ZHENG Nan, WANG Jia-qi. Structure and Catalytic Mechanism of Bacterial Urease Protein[J]. Biotechnology Bulletin, 2020, 36(12): 208-217.

Figures/Tables 7

References 56

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