Biotechnology Bulletin ›› 2022, Vol. 38 ›› Issue (10): 18-28.doi: 10.13560/j.cnki.biotech.bull.1985.2021-1572
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ZHAO Yu-xue1(), WANG Yun2, YU Lu-yao3, LIU Jing-jing1, SI Jin-ping1, ZHANG Xin-feng1(), ZHANG Lei1,2,3()
Received:
2021-12-20
Online:
2022-10-26
Published:
2022-11-11
Contact:
ZHANG Xin-feng,ZHANG Lei
E-mail:786330520@qq.com;zhangxf73@163.com;starzhanglei@aliyun.com
ZHAO Yu-xue, WANG Yun, YU Lu-yao, LIU Jing-jing, SI Jin-ping, ZHANG Xin-feng, ZHANG Lei. Structure and Application of C-glycosyltransferases in Plants[J]. Biotechnology Bulletin, 2022, 38(10): 18-28.
序号 Number | 基因名称 Gene name | 基因ID Gene ID | 植物来源 Species | 糖受体 Sugar receptor | 糖供体 Sugar donor | 参考文献 Reference |
---|---|---|---|---|---|---|
1 | OsCGT | CAQ77160 | 水稻Oryza sativa | 黄酮 | UDP-Glc UDP-Ara | [ |
2 | UGT708A6 | NP_001132650.1 | 玉米Zea mays | 黄酮 二氢黄酮 | UDP-Glc | [ |
3 | FeCGTa(UGT708C1) | BAP90360 | 荞麦Fagopyrum esculentum | 二氢查耳酮 二氢黄酮 | UDP-Glc UDP-Xyl | [ |
4 | FeCGTb(UGT708C2) | BAP90361 | 荞麦F. esculentum | 二氢查耳酮 二氢黄酮 | UDP-Glc UDP-Xyl | [ |
5 | UGT708D1 | BAR73279 | 大豆Glycine max | 黄烷酮 黄酮 | UDP-Glc | [ |
6 | GtUF6CGT1 | BAQ19550 | 三花龙胆Gentiana triflora | 黄酮 | UDP-Glc | [ |
7 | MiCGT | ALD83754 | 芒果Mangifera indica | 苯丙素 | UDP-Glc | [ |
8 | MiCGTb | AMM73095 | 芒果M. indica | 苯丙素 | UDP-Glc | [ |
9 | PlUGT43 | A0A172J2G3.2 | 葛根Pueraria lobata | 异黄酮 | UDP-Glc | [ |
10 | FcCGT(UGT708G1) | BBA18062 | 金柑Fortunella crassifolia | 二氢查耳酮 二氢黄酮 | UDP-Glc UDP-Xyl UDP-Gal | [ |
11 | CuCGT(UGT708G2) | BBA18063 | 温州蜜柑Citrus unshiu | 二氢查耳酮 二氢黄酮 | UDP-Glc UDP-Xyl UDP-Gal | [ |
12 | TcCGT1 | MK644229 | 中国金莲花Trollius chinensis | 黄酮 黄酮醇 二氢查尔酮 | UDP-Xyl UDP-Gal UDP-Ara | [ |
13 | WjGT1 | LC465149 | 块茎山萮菜Eutrema japonicum | 黄酮 黄酮醇 二氢查耳酮 | UDP-Glc | [ |
14 | GgCGT | MH998596 | 光果甘草Glycyrrhiza glabra | 二氢查耳酮 异黄酮 | UDP-Glc UDP-Xyl UDP-Gal UDP-Ara | [ |
15 | OsUGT708A4 | Q5VMG8 | 水稻O. sativa | 二氢黄酮 二氢查耳酮 | UDP-Glc | [ |
16 | OsUGT708A2 | Q5VME5 | 水稻O. sativa | 二氢黄酮 二氢查耳酮 | UDP-Glc | [ |
17 | OsUGT708A1 | A2YBW7 | 水稻O. sativa | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
18 | OsUGT708A39 | A2YBW8 | 水稻O. sativa | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
19 | OsUGT708A40 | A2YBX1 | 水稻O. sativa | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
20 | ZmUGT708A5 | B6SWX3 | 玉米Z. mays | 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
21 | ZmUGT708A11 | A0A1D6LXE6 | 玉米Z. mays | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
22 | ZmUGT708A41 | B4FAN3 | 玉米Z. mays | 二氢黄酮 二氢查耳酮 | UDP-Glc | [ |
23 | ZmUGT708A42 | B4FM13 | 玉米Z. mays | 二氢黄酮 二氢查耳酮 | UDP-Glc | [ |
24 | SbUGT708A36 | C5Z8Y8 | 高粱Sorghum bicolor | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
25 | SbUGT708A35 | C5Z8Y5 | 高粱S. bicolor | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
26 | SbUGT708A34 | C5Z8Y2 | 高粱S. bicolor | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
27 | SbUGT708A38 | A0A194YGR9 | 高粱S. bicolor | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
28 | TaUGT708A14 | A0A3B6RGT4 | 小麦Triticum aestivum | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
29 | TaUGT708A52 | A0A3B6SEV6 | 小麦T. aestivum | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
30 | TaUGT708A53 | A0A3B6TPG6 | 小麦T. aestivum | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
31 | TaUGT708A15 | A0A3B6RGR9 | 小麦T. aestivum | 二氢黄酮 二氢查耳酮 | UDP-Glc | [ |
32 | TaUGT708A54 | A0A3B6SB95 | 小麦T. aestivum | 二氢黄酮 二氢查耳酮 | UDP-Glc | [ |
33 | TaUGT708A55 | A0A3B6TNL8 | 小麦T. aestivum | 二氢黄酮 | UDP-Glc | [ |
34 | BdUGT708A7 | I1GYZ6 | 二穗短柄草 Brachypodium distachyon | 二氢黄酮 二氢查耳酮 | UDP-Glc | [ |
35 | BdUGT708A8 | I1GZD7 | 二穗短柄草B. distachyon | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
36 | SiUGT708A31 | K3XWN4 | 小米Setaria italica | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
37 | SiUGT708A32 | K3XWJ1 | 小米S. italica | 二氢黄酮 二氢查耳酮 | UDP-Glc | [ |
38 | SiUGT708A33 | K3Y181 | 小米S. italica | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
39 | PhUGT708A43 | MK616588 | 毛竹Phyllostachys heterocycla | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
40 | PhUGT708A46 | MK616589 | 毛竹P. heterocycla | 二氢黄酮 二氢查耳酮 | UDP-Glc | [ |
41 | PhUGT708A48 | MK616590 | 毛竹P. heterocycla | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
42 | PhUGT708A50 | MK616591 | 毛竹P. heterocycla | 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
43 | PgUGT708A44 | MK616592 | 淡竹P. heterocycla | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
44 | PpUGT708A45 | MK616593 | 高节竹Phyllostachys prominens | 二氢查耳酮 | UDP-Glc | [ |
45 | DcaCGT | MT452646 | 铁皮石斛Dendrobium catenatum | 二氢黄酮 二氢查耳酮 | UDP-Glc | [ |
46 | NnCGT1(UGT708N1) | LOC104598527 | 莲Nelumbo nucifera | 黄酮 | UDP-Glc | [ |
47 | NnCGT2(UGT708N2) | LOC104603347 | 莲N. nucifera | 黄酮 | UDP-Ara UDP-Xyl | [ |
48 | SbCGT | MK894443 | 黄芩Scutellaria baicalensis | 黄酮 | UDP-Glc UDP-Ara | [ |
49 | LpCGT | MK894451 | 兰氏萍Landoltia punctata | 黄酮 | UDP-Glc UDP-Ara | [ |
50 | AbCGT | MN747045 | 芦荟Aloe barbadensis | 二氢查尔酮酚 | UDP-Glc | [ |
Table 1 Summary of reported CGT gene studies
序号 Number | 基因名称 Gene name | 基因ID Gene ID | 植物来源 Species | 糖受体 Sugar receptor | 糖供体 Sugar donor | 参考文献 Reference |
---|---|---|---|---|---|---|
1 | OsCGT | CAQ77160 | 水稻Oryza sativa | 黄酮 | UDP-Glc UDP-Ara | [ |
2 | UGT708A6 | NP_001132650.1 | 玉米Zea mays | 黄酮 二氢黄酮 | UDP-Glc | [ |
3 | FeCGTa(UGT708C1) | BAP90360 | 荞麦Fagopyrum esculentum | 二氢查耳酮 二氢黄酮 | UDP-Glc UDP-Xyl | [ |
4 | FeCGTb(UGT708C2) | BAP90361 | 荞麦F. esculentum | 二氢查耳酮 二氢黄酮 | UDP-Glc UDP-Xyl | [ |
5 | UGT708D1 | BAR73279 | 大豆Glycine max | 黄烷酮 黄酮 | UDP-Glc | [ |
6 | GtUF6CGT1 | BAQ19550 | 三花龙胆Gentiana triflora | 黄酮 | UDP-Glc | [ |
7 | MiCGT | ALD83754 | 芒果Mangifera indica | 苯丙素 | UDP-Glc | [ |
8 | MiCGTb | AMM73095 | 芒果M. indica | 苯丙素 | UDP-Glc | [ |
9 | PlUGT43 | A0A172J2G3.2 | 葛根Pueraria lobata | 异黄酮 | UDP-Glc | [ |
10 | FcCGT(UGT708G1) | BBA18062 | 金柑Fortunella crassifolia | 二氢查耳酮 二氢黄酮 | UDP-Glc UDP-Xyl UDP-Gal | [ |
11 | CuCGT(UGT708G2) | BBA18063 | 温州蜜柑Citrus unshiu | 二氢查耳酮 二氢黄酮 | UDP-Glc UDP-Xyl UDP-Gal | [ |
12 | TcCGT1 | MK644229 | 中国金莲花Trollius chinensis | 黄酮 黄酮醇 二氢查尔酮 | UDP-Xyl UDP-Gal UDP-Ara | [ |
13 | WjGT1 | LC465149 | 块茎山萮菜Eutrema japonicum | 黄酮 黄酮醇 二氢查耳酮 | UDP-Glc | [ |
14 | GgCGT | MH998596 | 光果甘草Glycyrrhiza glabra | 二氢查耳酮 异黄酮 | UDP-Glc UDP-Xyl UDP-Gal UDP-Ara | [ |
15 | OsUGT708A4 | Q5VMG8 | 水稻O. sativa | 二氢黄酮 二氢查耳酮 | UDP-Glc | [ |
16 | OsUGT708A2 | Q5VME5 | 水稻O. sativa | 二氢黄酮 二氢查耳酮 | UDP-Glc | [ |
17 | OsUGT708A1 | A2YBW7 | 水稻O. sativa | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
18 | OsUGT708A39 | A2YBW8 | 水稻O. sativa | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
19 | OsUGT708A40 | A2YBX1 | 水稻O. sativa | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
20 | ZmUGT708A5 | B6SWX3 | 玉米Z. mays | 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
21 | ZmUGT708A11 | A0A1D6LXE6 | 玉米Z. mays | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
22 | ZmUGT708A41 | B4FAN3 | 玉米Z. mays | 二氢黄酮 二氢查耳酮 | UDP-Glc | [ |
23 | ZmUGT708A42 | B4FM13 | 玉米Z. mays | 二氢黄酮 二氢查耳酮 | UDP-Glc | [ |
24 | SbUGT708A36 | C5Z8Y8 | 高粱Sorghum bicolor | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
25 | SbUGT708A35 | C5Z8Y5 | 高粱S. bicolor | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
26 | SbUGT708A34 | C5Z8Y2 | 高粱S. bicolor | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
27 | SbUGT708A38 | A0A194YGR9 | 高粱S. bicolor | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
28 | TaUGT708A14 | A0A3B6RGT4 | 小麦Triticum aestivum | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
29 | TaUGT708A52 | A0A3B6SEV6 | 小麦T. aestivum | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
30 | TaUGT708A53 | A0A3B6TPG6 | 小麦T. aestivum | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
31 | TaUGT708A15 | A0A3B6RGR9 | 小麦T. aestivum | 二氢黄酮 二氢查耳酮 | UDP-Glc | [ |
32 | TaUGT708A54 | A0A3B6SB95 | 小麦T. aestivum | 二氢黄酮 二氢查耳酮 | UDP-Glc | [ |
33 | TaUGT708A55 | A0A3B6TNL8 | 小麦T. aestivum | 二氢黄酮 | UDP-Glc | [ |
34 | BdUGT708A7 | I1GYZ6 | 二穗短柄草 Brachypodium distachyon | 二氢黄酮 二氢查耳酮 | UDP-Glc | [ |
35 | BdUGT708A8 | I1GZD7 | 二穗短柄草B. distachyon | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
36 | SiUGT708A31 | K3XWN4 | 小米Setaria italica | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
37 | SiUGT708A32 | K3XWJ1 | 小米S. italica | 二氢黄酮 二氢查耳酮 | UDP-Glc | [ |
38 | SiUGT708A33 | K3Y181 | 小米S. italica | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
39 | PhUGT708A43 | MK616588 | 毛竹Phyllostachys heterocycla | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
40 | PhUGT708A46 | MK616589 | 毛竹P. heterocycla | 二氢黄酮 二氢查耳酮 | UDP-Glc | [ |
41 | PhUGT708A48 | MK616590 | 毛竹P. heterocycla | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
42 | PhUGT708A50 | MK616591 | 毛竹P. heterocycla | 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
43 | PgUGT708A44 | MK616592 | 淡竹P. heterocycla | 二氢黄酮 二氢查耳酮 | UDP-Glc UDP-Ara | [ |
44 | PpUGT708A45 | MK616593 | 高节竹Phyllostachys prominens | 二氢查耳酮 | UDP-Glc | [ |
45 | DcaCGT | MT452646 | 铁皮石斛Dendrobium catenatum | 二氢黄酮 二氢查耳酮 | UDP-Glc | [ |
46 | NnCGT1(UGT708N1) | LOC104598527 | 莲Nelumbo nucifera | 黄酮 | UDP-Glc | [ |
47 | NnCGT2(UGT708N2) | LOC104603347 | 莲N. nucifera | 黄酮 | UDP-Ara UDP-Xyl | [ |
48 | SbCGT | MK894443 | 黄芩Scutellaria baicalensis | 黄酮 | UDP-Glc UDP-Ara | [ |
49 | LpCGT | MK894451 | 兰氏萍Landoltia punctata | 黄酮 | UDP-Glc UDP-Ara | [ |
50 | AbCGT | MN747045 | 芦荟Aloe barbadensis | 二氢查尔酮酚 | UDP-Glc | [ |
蛋白质ID PDB ID | 描述Description | 植物来源Species | 参考文献Reference |
---|---|---|---|
6JTD | TcCGT1与UDP复合的晶体结构 | 中国金莲花T. chinensis | [ |
6L5P | GgCGT与UDP-Glu复合物的晶体结构 | 光果甘草G. glabra | [ |
6LLW | UGT708C1与UDP复合的晶体结构 | 荞麦F. esculentum | [ |
6LF6 | ZmCGTa与UDP复合的晶体结构 | 玉米Z. mays | [ |
6LG0 | SbCGTa与UDP复合的晶体结构 | 黄芩S. baicalensis | [ |
6LG1 | LpCGTa与UDP复合物的晶体结构 | 兰氏萍L. punctata | [ |
Table 2 Resolved crystal structures of available CGT proteins
蛋白质ID PDB ID | 描述Description | 植物来源Species | 参考文献Reference |
---|---|---|---|
6JTD | TcCGT1与UDP复合的晶体结构 | 中国金莲花T. chinensis | [ |
6L5P | GgCGT与UDP-Glu复合物的晶体结构 | 光果甘草G. glabra | [ |
6LLW | UGT708C1与UDP复合的晶体结构 | 荞麦F. esculentum | [ |
6LF6 | ZmCGTa与UDP复合的晶体结构 | 玉米Z. mays | [ |
6LG0 | SbCGTa与UDP复合的晶体结构 | 黄芩S. baicalensis | [ |
6LG1 | LpCGTa与UDP复合物的晶体结构 | 兰氏萍L. punctata | [ |
Fig. 3 Protein crystal structure of structurally resolved plant CGT A shows the crystal structure of plant CGT with structure resolution. B shows the results of protein sequence comparison. C shows the structural domain comparison of protein secondary structure
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