Advances in fat-1 Transgenic Animals

Abstract

Abstract: Mammals engineered by fat-1 gene from Caenorhabditis elegans can convert n-6 polyunsaturated fatty acids（PUFAs）to n-3PUFAs，and decrease the ratio of n-6/n-3 PUFAs in vivo. Although n-3 polyunsaturated fatty acids have been shown to play an important role inhealth，and can reduce the risk of many diseases，humans can not synthesize the n-3 PUFAs automatically. This review summarized the statusof research about fat-1 gene and fat-1 transgenic animals.

Key words: fat-1 gene, Transgenic animal n-3, PUFAs

Yang Huiting, Wang Hongmei, Fang Yongzhi, Liu Wenhao, Wu Jianming, He Hongbin. Advances in fat-1 Transgenic Animals[J]. Biotechnology Bulletin, 2012, 0(12): 8-12.

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