Roles of POZ-ZF Proteins in Development and Oncogenesis

Abstract

Abstract: POZ-ZF proteins are highly conserved proteins implicated many biological processes in invertebrate and vertebrate. Members of the POZ-ZF protein contain an amino-terminal POZ domain and a carboxy-terminal DNA-binding domain made of one or more zinc finger motifs and usually act as transcriptional co-repressors to regulate target genes expression. Recent studies showed that POZ-ZF proteins play important roles in development and oncogenesis. In this review, we summarize studies of five POZ-ZF proteins, which is helpful to further understand POZ-ZF proteins.

Key words: POZ-ZF protein, Development, Oncogenesis

Mei Zhu, Yang Yutao, Xu Zhiqing. Roles of POZ-ZF Proteins in Development and Oncogenesis[J]. Biotechnology Bulletin, 2013, 0(2): 55-60.

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