Developments in Mammalian Orthoreovirus Reverse Genetics Research

Abstract

Abstract: One of the most widely distributed virus groups is Reoviridae. Mammalian orthoreovirus(MRV)is belonged to the orthoreovirus, which mainly infected the respiratory and gastrointestinal tracts of virtually all mammals, including humans. The MRV reverse genetics have improved significantly in recent years. There are several progresses in MRV genome packaging, gene function and pathogenesis based on this technology. Recent advances on the establishment of MRV reverse genetics and its application are discussed in the text.

Key words: Mammalian orthoreovirus, Reverse, Genetics, Gene function, Pathogenesis

Ke Fei, Wang Yun, Hou Lifan,g Hu Xing'an, Li Peipei. Developments in Mammalian Orthoreovirus Reverse Genetics Research[J]. Biotechnology Bulletin, 2014, 0(5): 15-19.

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