Research Progress on the Role of COP9 Signalosome in Growth,Development and Secondary Metabolism of Fungus

doi:10.13560/j.cnki.biotech.bull.1985.2017.05.003

Abstract

Abstract: The COP9 signalosome（CSN）is a highly conserved protein complex in eukaryotes,and is involved in the control of the whole life. At present,the researches on COP9 signalosome are mainly concentrated in humans,animals and plants. The research on fungal COP9 signalosome is mainly focused on several patterns of fungi,relatively few on other fungi,and even less in China. In this paper,we summarized the composition and structure traits,the related regulation mechanisms for growth and development,and the coordination of secondary metabolism of fungal COP9 signalosome. Further,we analyzed the existing doubts about COP9 signalosome,aiming at providing references for further studying the functions of COP9 signalosome in fungus.

Key words: COP9 signalosome, fungus, growth, development, secondary metabolism

QIAO Yu, YANG Shui-ying, LI Zhen-lun, WANG Fang, XU Yi. Research Progress on the Role of COP9 Signalosome in Growth,Development and Secondary Metabolism of Fungus[J]. Biotechnology Bulletin, 2017, 33(5): 19-25.

References

[1] Berovic M, Legisa M. Citric acid production[J]. Biotechnology Annual Review, 2007, 13：303-343.
[2] Singh O V, Kumar R. Biotechnological production of gluconic acid：future implications[J]. Applied Microbiology and Biotechnology, 2007, 75（4）：713-722.
[3] Kobayashi T, Abe K, Asai K, et al. Genomics of Aspergillus oryzae[J]. Biosci Biotechnol Biochemi, 2007, 71（3）：646-670.
[4] Normile D. Spoiling for a fight with mold[J]. Science, 2010, 327（5967）：807.
[5] Wei N, Chamovitz DA, Deng XW. Arabidopsis COP9 is a component of a novel signaling complex mediating light control of development[J]. Cell, 1994, 78（1）：117-124.
[6] Schwechheimer C, Isono E. The COP9 signalosome and its role in plant development[J]. Eur J Cell Biol, 2010, 89：157-162.
[7] Oren-Giladi P, Krieger O, Edgar B A, et al. Cop9 signalosome subunit 8（CSN8）is essential for Drosophila development[J]. Genes to Cells, 2008, 13（3）：221-231.
[8] Gummlich L, Rabien A, Jung K, et al. Deregulation of the COP9 signalosome-cullin-RING ubiquitin-ligase pathway：Mechanisms and roles in urological cancers[J]. International Journal of Biochemistry and Cell Biology, 2013, 45（7）：1327-1337.
[9] Schütz AK, Hennes T, Jumpertz S, et al. Role of CSN5/JAB1 in Wnt/β-catenin activation in colorectal cancer cells[J]. FEBS Lett, 2012, 586（11）：1645-1651.
[10] Hann R, Dubiel W. COP9 signalosome function in the DDR[J]. FEBS Lett, 2011, 585（18）：2845-2852.
[11] Chamovitz DA. Revisiting the COP9 signalosome as a transcriptio-nal regulator[J]. EMBO Reports, 2009, 10（4）：352-358.
[12] Su H, Huang W, Wang X. The COP9 signalosome negatively regulates proteasome proteolytic function and is essential to transcription[J]. Int J Biochem Cell Biol, 2009, 3：615-624.
[13] Wei N, Serino G, Deng XW. The COP9 signalosome：more than a protease[J]. Trends Biochem Sci, 2008, 33（12）：592-600.
[14] Braus GH, Irniger S, Bayram Ö. Fungal development and the COP9 signalosome[J]. Curr Opin Microbiol, 2010, 13（6）：672-676.
[15] Nahlik K, Dumkow M, Bayram Ö, et al. The COP9 signalosome mediates transcriptional and metabolic response to hormones, oxid-ative stress protection and cell wall rearrangement during fungal development[J]. Mol Microbiol, 2010, 78（4）：964-979.
[16] Licursi V, Salvi C, De Cesare V, et al. The COP9 signalosome is involved in the regulation of lipid metabolism and of transition metals uptake in Saccharomyces cerevisiae[J]. FEBS Journal, 2014, 281（1）：175-190.
[17] 李娜. 营养元素对烟草疫霉生长发育及硼对产孢期基因转录的影响[D]. 重庆：西南大学, 2014.
[18] Pick E, Golan A, Zimbler JZ, et al. The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN-domain[J]. PLoS One, 2012, 7（8）：e43980.
[19] Gerke J, Braus GH. Manipulation of fungal development as source of novel secondary metabolites for biotechnology[J]. Applied Microbiology and Biotechnology, 2014, 98（20）：8443-8455.
[20] Scheel H, Hofmann K. Prediction of a common structural scaffold for proteasome lid, COP9-signalosome and eIF3 complexes[J]. BMC Bioinformatics, 2005, 6（1）：71.
[21] Cope GA, Suh GSB, Aravind L, et al. Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1[J]. Science, 2002, 298（5593）：608-611.
[22] Zhang H, Gao ZQ, Wang W J, et al. The crystal structure of the MPN domain from the COP9 signalosome subunit CSN6[J]. FEBS Lett, 2012, 586（8）：1147-1153.
[23] Tsuge T, Matsui M, Wei N. The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain[J]. Journal of Molecular Biology, 2001, 305（1）：1-9.
[24] Verma R, Aravind L, Oania R, et al. Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome[J]. Science, 2002, 298（5593）：611-615.
[25] Yao T, Cohen RE. A cryptic protease couples deubiquitination and degradation by the proteasome[J]. Nature, 2002, 419（6905）：403-407.
[26] Pick E, Pintard L. In the land of the rising sun with the COP9 signalosome and related Zomes. Symposium on the COP9 signalosome, proteasome and eIF3[J]. EMBO Reports, 2009, 10（4）：343-348.
[27] Feldman RMR, Correll CC, et al. A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p[J]. Cell, 1997, 91（2）：221-230.
[28] Skowyra D, Craig KL, Tyers M, et al. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex[J]. Cell, 1997, 91（2）：209-219.
[29] Kawakami T, Chiba T, et al. NEDD8 recruits E2-ubiquitin to SCF E3 ligase[J]. EMBO Journal, 2001, 20（15）：4003-4012.
[30] Sakata E, Yamaguchi Y, Miyauchi Y, et al. Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity[J]. Nature Structural and Molecular Biology, 2007, 14（2）：167-168.
[31] Wang J, Hu Q, Chen H, et al. Role of individual subunits of the Neurospora crassa CSN complex in regulation of deneddylation and stability of cullin proteins[J]. PLoS Genetics, 2010, 6（12）：e1001232.
[32] He Q, Cheng P, He Q, et al. The COP9 signalosome regulates the Neurospora circadian clock by controlling the stability of the SCFFWD-1 complex[J]. Genes Dev, 2005a, 13：1518-1531.
[33] He Q, Liu Y. Degradation of the Neurospora circadian clock protein frequency through the ubiquitin-proteasome pathway[J]. Biochemical Society Transactions, 2005b, 33（5）：953-956.
[34] Liu Y, Bell-Pedersen D. Circadian rhythms in Neurospora crassa and other filamentous fungi[J]. Eukaryotic Cell, 2006, 5（8）：1184-1193.
[35] Rodriguez-Romero J, Hedtke M, Kastner C, et al. Fungi, hidden in soil or up in the air：light makes a difference[J]. Microbiology, 2010, 64（1）：585-610.
[36] Bayram Ö, Braus GH, Fischer R, et al. Spotlight on Aspergillus nidulans photosensory systems[J]. Fungal Genetics and Biology, 2010, 47（11）：900-908.
[37] Busch S, Eckert SE, Krappmann S, et al. The COP9 signalosome is an essential regulator of development in the filamentous fungus Aspergillus nidulans[J]. Mol Microbiol, 2003, 3：717-730.
[38] Bayram Ö, Krappmann S, Ni M, et al. VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism[J]. Science, 2008, 320（5882）：1504-1506.
[39] Purschwitz J, Müller S, Fischer R. Mapping the interaction sites of Aspergillus nidulans phytochrome FphA with the global regulator VeA and the White Collar protein LreB[J]. Molecular Genetics and Genomic, 2009, 281（1）：35-42.
[40] Tsitsigiannis DI, Zarnowski R, Keller NP. The lipid body protein, PpoA, coordinates sexual and asexual sporulation in Aspergillus nidulans[J]. J Biol Chemi, 2004a, 279（12）：11344-11353.
[41] Tsitsigiannis DI, Kowieski TM, Zarnowski R, et al. Endogenous lipogenic regulators of spore balance in Aspergillus nidulans[J]. Eukaryotic Cell, 2004b, 3（6）：1398-1411.
[42] Tsitsigiannis DI, et al. Three putative oxylipin biosynthetic genes integrate sexual and asexual development in Aspergillus nidulans[J]. Microbiology, 2005, 151（6）：1809-1821.
[43] Brodhun F, Feussner I. Oxylipins in fungi[J]. FEBS Journal, 2011, 278（7）：1047-1063.
[44] Bayram Ö, Braus GH. Coordination of secondary metabolism and development in fungi：the velvet family of regulatory proteins[J]. FEMS Microbiology Reviews, 2012, 36（1）：1-24.
[45] Skropeta D. Deep-sea natural products[J]. Natural Product Reports, 2008, 25（6）：1131-1166.
[46] Calvo AM, Wilson RA, Bok JW, et al. Relationship between secondary metabolism and fungal development[J]. Microbiology and Molecular Biology Reviews, 2002, 66（3）：447-459.
[47] Yu JH, Keller N. Regulation of secondary metabolism in filament-ous fungi[J]. Annua Rev Phytopathol, 2005, 43：437-458.
[48] Dohmann EMN, Nill C, et al. DELLA proteins restrain germination and elongation growth in Arabidopsis thaliana COP9 signalosome mutants[J]. Eur J Cell Biol, 2010, 89（2）：163-168.
[49] Hind SR, Pulliam SE, Veronese P, et al. The COP9 signalosome controls jasmonic acid synthesis and plant responses to herbivory and pathogens[J]. Plant Journal, 2011, 65（3）：480-491.
[50] Wang J, Yu Y, Zhang Z, et al. Arabidopsis CSN5B interacts with VTC1 and modulates ascorbic acid synthesis[J]. Plant Cell, 2013, 25（2）：625-636.
[51] Helmstaedt K, Schwier EU, et al. Recruitment of the inhibitor Cand1 to the cullin substrate adaptor site mediates interaction to the neddylation site[J]. Mol Biol Cell, 2011, 22（1）：153-164.
[52] Min KW, Kwon MJ, Park HS, et al. CAND1 enhances deneddylation of CUL1 by COP9 signalosome[J]. Biochemical and Biophysical Research Communications, 2005, 334（3）：867-874.
[53] Gerke J, et al. Breaking the silence：protein stabilization uncovers silenced biosynthetic gene clusters in the fungus Aspergillus nidu-lans[J]. Appl Environ Microbiol, 2012, 78（23）：8234-8244.
[54] Suzuki T, Tanemura K, Okada C, et al. Synthesis of 7-acetyloxy-3, 7-dimethy1-7, 8-dihydro-6H-isochromene-6, 8-dione and its analogues[J]. Journal of Heterocyclic Chemistry, 2001, 38（6）：1409-1418.
[55] Osmanova N, Schultze W, Ayoub N. Azaphilones：a class of fungal metabolites with diverse biological activities[J]. Phytochemistry Reviews, 2010, 9（2）：315-342.
[56] Yasukawa K, Takahashi M, Natori S, et al. Azaphilones inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mice[J]. Oncology, 1994, 1：108-112.
[57] Mapari SAS, Thrane U, Meyer AS. Fungal polyketide azaphilone pigments as future natural food colorants?[J]. Trends in Biotechnology, 2010, 28（6）：300-307.
[58] Galagan JE, Calvo SE, Cuomo C, et al. Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae[J]. Nature, 2005, 438（7071）：1105-1115.
[59] Krappmann S, Jung N, Medic B, et al. The Aspergillus nidulans F-box protein GrrA links SCF activity to meiosis[J]. Molecular Microbiology, 2006, 61（1）：76-88.
[60] Georgianna DR, Payne GA. Genetic regulation of aflatoxin biosynthesis：from gene to genome[J]. Fungal Genetics & Biology, 2009, 46（2）：113-125.