Research Progress of Gene Editing Technology on Cattle

doi:10.13560/j.cnki.biotech.bull.1985.2018-0413

Abstract

Abstract: Gene editing technology is an emerging biotechnology for site-directed modification of the genome,including zinc-finger nuclease（ZFN）technology,transcriptional activator-like effect nuclease（TALEN）technology and the recently developed CRISPR/Cas9 technology,which has exerted unprecedented influence in the breeding of the animal and plant,biopharmaceuticals and gene therapy,etc. In this review,we summarize the brief history of gene targeting and gene editing technology,and highlight the research progress of gene editing technology in the fields of the resistance of disease,the improvement of milk quality and lean meat percentage,and the cultivation of new varieties such as hornless cattle. Finally,we also propose the establishment of a gene editing plants and animals’ supervision system to speed up the industrialization of genetic engineering animals in China.

Key words: gene editing technology, ZFNs, TALENs, Cas9, cow genetic improvement, gene editing biology regulatory policy

TANG Bo, SUN Zhao-lin, DAI Yun-ping. Research Progress of Gene Editing Technology on Cattle[J]. Biotechnology Bulletin, 2018, 34(5): 41-47.

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